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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Renal inflammatory and oxidative and metabolic changes after 6 weeks of cafeteria diet in rats

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Maria Eugênia Lopes Navarro ; Klinsmann Carolo dos Santos ; André Ferreira do Nascimento ; Fabiane Valentini Francisqueti ; Igor Otávio Minatel ; Damiana Tortolero Pierine ; Renata Azevedo de Melo Luvizotto ; Ana Lúcia A. Ferreira ; Dijon Henrique Salomé de Campos ; Camila Renata Corrêa
Total Authors: 10
Document type: Journal article
Source: J. Bras. Nefrol.; v. 38, n. 1, p. 9-14, Mar. 2016.

Abstract Introduction: Obesity is a disease in which inflammation is directly involved and can lead to impaired renal function. Objective: To evaluate the influence of short term exposure to cafeteria diet on kidney tissue inflammation and advanced glycation end products (AGEs) in the rat plasma. Methods: Male Wistar rats (10 weeks of age, weighing 350 g) were assigned to receive commercial chow diet (C; n = 8 animals/group, 5% of energy from fat) or cafeteria diet (CAF-D, n = 8 animals/group: 29% energy fat) and sucrose in drinking water (300 g/L) for 6 weeks. Results: adiposity index at six weeks was higher in CAF-D group compared to C. The same behavior was observed for plasma levels of glucose, triglycerides, leptin, insulin and AGEs. The gene expression of IL-6 and TNF-α in renal tissue was higher in CAF-D group and no significant difference in adipose tissue. There was no increase of these cytokines in plasma and kidney or histologically. There was a significant decrease of adiponectin in the CAF-D group. Conclusion: The short exposure CAF-D reflects changes in metabolism, increased plasma levels of AGEs, which may reflect the increased expression of inflammatory cytokines in the kidney. (AU)

FAPESP's process: 11/14132-0 - Role of TLR-4 in the inflammatory response and insulin resistance in adipose tissue in a chronic nutritional overload
Grantee:Camila Renata Corrêa
Support type: Regular Research Grants