Novel flow injection spectrophotometric determination of ranitidine in pharmaceuticals

Author(s)

Vicentini, Fernando Campanha ^[1] ; Janegitz, Bruno C. ^[2] ; Bonifacio, Viviane G. ^[3] ; Fatibello-Filho, Orlando ^[4] ; Marcolino-Junior, Luiz H. ^[5]

Affiliation

^[1] Univ Fed Sao Carlos, Ctr Nat Sci, BR-18290000 Buri - Brazil

^[2] Univ Fed Sao Carlos, Dept Nat Sci Math & Educ, BR-13600970 Araras - Brazil

^[3] State Univ Goias, BR-75001970 Anapolis - Brazil

^[4] Univ Fed Sao Carlos, Dept Chem, BR-13560970 Sao Carlos, SP - Brazil

^[5] Univ Fed Parana, Dept Chem, BR-81531980 Curitiba, Parana - Brazil

• Document type: Journal article
• Source: Canadian Journal of Chemistry; v. 94, n. 7, p. 604-607, JUL 2016.
• Web of Science Citations: 1

Abstract

A novel flow injection spectrophotometric determination of ranitidine in pharmaceuticals is reported. The method is based on a compound formed in a reaction using ranitidine with and potassium permanganate in neutral media, which can be monitored at 430 nm. Under optimal conditions, an analytical curve was constructed, which was linear in the range between 5.0 x 10(-5) and 1.0 x 10(-3) mol L-1 with a detection limit of 1.0 x 10(-5) mol L-1. In addition, the sample throughput was 60 h(-1) and the obtained results for commercial formulation samples by applying the proposed method were in good agreement with labeled values and those obtained by a reference method at a 95% confidence level. (AU)

• FAPESP's process: 15/19099-2 - Development of electrochemical sensors and biosensors for different analytical purposes
• Grantee: Bruno Campos Janegitz
• Support Opportunities: Regular Research Grants