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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Antiprotozal and Antihelminthic Evaluation of the Hydroalcoholic Extract, Fractions and Compounds of Gochnatia pulchra

Author(s):
Lucarini, Rodrigo [1] ; Magalhaes, Lizandra G. [1] ; Rodrigues, Vanderlei [2] ; Souza, Julia M. [1] ; Tozatti, Marcos G. [1] ; Pires, Regina H. [3] ; Cunha, Wilson R. [1] ; Martins, Carlos H. G. [1]
Total Authors: 8
Affiliation:
[1] Univ Franca, Res Nucleus Exact & Technol Sci, Franca, SP - Brazil
[2] Univ Sao Paulo, Sch Med, Dept Biochem & Immunol, Ribeirao Preto, SP - Brazil
[3] Univ Franca, Hlth Promot Nucleus, Franca, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Latin American Journal of Pharmacy; v. 35, n. 4, p. 762-767, MAY 2016.
Web of Science Citations: 1
Abstract

The genus Gochnatia (Asteraceae) comprises 70 species that occur mainly in America, from Mexico to Argentine. The chemical composition and specific pharmacological activities of these species have been poorly investigated. This study aimed to investigate the in vitro antiprotozoal and antihelmintic activities of the hydroalcoholic extract, fractions, and compounds of Gochnatia pulchra. The hexanic fraction (111) and apigenin (APG) showed moderate activity against the promastigote forms of Leishmania amazonensis, with IC50 values of 1205 +/- 6.4 and 50.02 +/- 1.4 mu g/mL, respectively. Against adult Schistosoma mansoni worms, the hydroalcoholic extract (HEGP) and the dichloromethane fraction (DF) displayed moderate activity. HEGP at 100 mu g/mL killed 100% of adult worms within 24 h, whereas DF at 50 mu g/mL and 100 mu g/mL killed 100% of of adult worms within 48 h and 24 h, respectively. All the other evaluated fractions and isolated compounds did not exert any effects on adult S. mansoni worms. This is the first report on the activity of plants belonging to the genus Gochnatia, and the present data have shown that exploring the biological activities of species of this genus is extremely important. (AU)

FAPESP's process: 12/16182-8 - Chemical study and biological assays with species of the cerrado searching to antiparasitic substances
Grantee:Wilson Roberto Cunha
Support Opportunities: Regular Research Grants
FAPESP's process: 10/02066-0 - Prospecting of biological chemistry Gochnatia pulchra in the development potential of antibacterial, anti-inflammatory and antiparasitic agents
Grantee:Rodrigo Lucarini
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 08/07329-0 - Bioprospection for antimicrobial and anti-inflammatory agents of the specie vegetable Gochnatia pulchra
Grantee:Rodrigo Lucarini
Support Opportunities: Scholarships in Brazil - Master