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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Optimizing the Water-Oil Emulsification Process for Developing CPC Microspheres

Full text
Author(s):
Caroline de Oliveira Renó [1] ; Mariana Motisuke [2]
Total Authors: 2
Affiliation:
[1] UNIFESP. Science and Technology Institute - Brasil
[2] UNIFESP. Science and Technology Institute - Brasil
Total Affiliations: 2
Document type: Journal article
Source: MATERIALS RESEARCH-IBERO-AMERICAN JOURNAL OF MATERIALS; v. 19, n. 6, p. 1388-1392, 2016-10-10.
Abstract

Spherical calcium phosphate cement carriers were synthesized by water/oil emulsion. A 23 factorial design was employed in order to optimize the size and form of the microspheres. Stirring speed, liquid-to-powder ratio and cement paste-to-oil ratio were varied in two different levels and the response variable was the microsphere's sphericity. The results showed that cement's setting reaction was responsible for stabilizing the microspheres within the oil phase resulting in a low crystalline hydroxyapatite. The sizes varied from 6.29 to 64.23 µm. From the factors studied, the stirring velocity and the interaction between the L/P ratio with the P/O ratio are the ones that are more effective in controlling microspheres' sphericity. The results suggest that the methodology studied may provide microspheres with appropriate properties to deliver cells and/or drugs without inducing inflammatory reactions. (AU)

FAPESP's process: 12/21198-0 - Bioactive and reabsorbable calcium phosphate microspheres for drug delivery
Grantee:Caroline de Oliveira Renó
Support type: Scholarships in Brazil - Master
FAPESP's process: 11/09240-9 - Calcium phosphate cement otimization for application in orthopedics and tissue engineering
Grantee:Mariana Motisuke
Support type: Regular Research Grants
FAPESP's process: 13/26248-9 - Strotium and silicon co-doped calcium phosphate cement: injectability evaluation and mechanical properties optimization
Grantee:Caroline de Oliveira Renó
Support type: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 13/19642-2 - Injectable bone cements: optimizing and controlling mechanical resistance, porosity and degradation rate
Grantee:Mariana Motisuke
Support type: Regular Research Grants