| Full text | |
| Author(s): |
Total Authors: 2
|
| Affiliation: | [1] UNIFESP. Science and Technology Institute - Brasil
[2] UNIFESP. Science and Technology Institute - Brasil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | MATERIALS RESEARCH-IBERO-AMERICAN JOURNAL OF MATERIALS; v. 19, n. 6, p. 1388-1392, 2016-10-10. |
| Abstract | |
Spherical calcium phosphate cement carriers were synthesized by water/oil emulsion. A 23 factorial design was employed in order to optimize the size and form of the microspheres. Stirring speed, liquid-to-powder ratio and cement paste-to-oil ratio were varied in two different levels and the response variable was the microsphere's sphericity. The results showed that cement's setting reaction was responsible for stabilizing the microspheres within the oil phase resulting in a low crystalline hydroxyapatite. The sizes varied from 6.29 to 64.23 µm. From the factors studied, the stirring velocity and the interaction between the L/P ratio with the P/O ratio are the ones that are more effective in controlling microspheres' sphericity. The results suggest that the methodology studied may provide microspheres with appropriate properties to deliver cells and/or drugs without inducing inflammatory reactions. (AU) | |
| FAPESP's process: | 12/21198-0 - Bioactive and reabsorbable calcium phosphate microspheres for drug delivery |
| Grantee: | Caroline de Oliveira Renó |
| Support type: | Scholarships in Brazil - Master |
| FAPESP's process: | 11/09240-9 - Calcium phosphate cement otimization for application in orthopedics and tissue engineering |
| Grantee: | Mariana Motisuke |
| Support type: | Regular Research Grants |
| FAPESP's process: | 13/26248-9 - Strotium and silicon co-doped calcium phosphate cement: injectability evaluation and mechanical properties optimization |
| Grantee: | Caroline de Oliveira Renó |
| Support type: | Scholarships in Brazil - Doctorate (Direct) |
| FAPESP's process: | 13/19642-2 - Injectable bone cements: optimizing and controlling mechanical resistance, porosity and degradation rate |
| Grantee: | Mariana Motisuke |
| Support type: | Regular Research Grants |