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Bioactive and reabsorbable calcium phosphate microspheres for drug delivery

Grant number: 12/21198-0
Support type:Scholarships in Brazil - Master
Effective date (Start): January 01, 2013
Effective date (End): March 31, 2014
Field of knowledge:Engineering - Materials and Metallurgical Engineering - Nonmetallic Materials
Principal researcher:Mariana Motisuke
Grantee:Caroline de Oliveira Renó
Home Institution: Instituto de Ciência e Tecnologia (ICT). Universidade Federal de São Paulo (UNIFESP). Campus São José dos Campos. São José dos Campos , SP, Brazil
Associated scholarship(s):13/03208-1 - Microspheres of calcium phosphate obtained by spray drying, BE.EP.MS


The number of patients that need biomedical implantations to substitute injured or damage bones is increasing because of the longer life expectancy, the number of obese people and to sedentary lifestyle, all of this is causing illnesses as osteoporosis. In order to develop materials able to attenuate these problems, the calcium phosphates (CaP), are interesting since they are biocompatible and bioactive. These materials have been used as dense blocks, scaffolds and granules. The last one presents irregular forms and sizes, but they had an increase in their applicability because of their higher rate of "in vivo" resorption. However, when used to deliver cells and / or drugs it is extremely essential to control the form and size. Therefore, becomes logical to develop CaP microspheres capable of treating diseases or induce new bone tissue growth. In this context, the objective of this project is to develop microspheres of calcium phosphate cement based on water-oil emulsification and spray-drying. The setting reaction of the cement will be responsible for the consolidation of microspheres removing the need for heat treatments at high temperatures. The methodologies proposed will develop national technology and, consequently, reduce the cost of the biomaterials used on the repair of bone defects.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
RENO, CAROLINE DE OLIVEIRA; MOTISUKE, MARIANA. Optimizing the Water-Oil Emulsification Process for Developing CPC Microspheres. MATERIALS RESEARCH-IBERO-AMERICAN JOURNAL OF MATERIALS, v. 19, n. 6, p. 1388-1392, . (12/21198-0, 13/26248-9, 13/19642-2, 11/09240-9)
RENO, CAROLINE DE OLIVEIRA; PERETA, NICHOLAS C.; BERTRAN, CELSO A.; MOTISUKE, MARIANA; DE SOUSA, ELIANDRA. Study of in vitro degradation of brushite cements scaffolds. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, v. 25, n. 10, p. 2297-2303, . (11/09240-9, 10/00863-0, 12/21198-0)

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