LIPID NANOSTRUCTURED CARRIERS SYSTEMS FOR IVERMECTIN AND METHOPRENE AIMING PARASITE CONTROL

Author(s)

Diego Faria Cola ^[1] ; Tatiane Pasquoto ^[2] ; Mariana Guilger ^[3] ; Renata de Lima ^[4] ; Camila Morais Gonçalves da Silva ^[5] ; Leonardo Fernandes Fraceto

Affiliation

^[1] Universidade Estadual Paulista Julio de Mesquita Filho. Departamento de Engenharia Ambiental - Brasil

^[2] Universidade de Sorocaba. Departamento de Biotecnologia - Brasil

^[3] Universidade de Sorocaba. Departamento de Biotecnologia - Brasil

^[4] Universidade de Sorocaba. Departamento de Biotecnologia - Brasil

^[5] Universidade Estadual de Campinas. Instituto de Biologia. Departamento de Bioquímica - Brasil

• Document type: Journal article
• Source: Química Nova; v. 39, n. 9, p. 1034-1043, 2016-11-00.

Abstract

The study of characteristics of nanoscale structures and applications now has great interest of researchers from different areas. In this regard, lipid carriers can improve the bioavailability of drugs and the reduction of possible toxicological effects. Thus, the development of nanostructured systems for the agricultural sector, aimed at combating parasites may reduce extensive damage caused to livestock producers and animal health. This study aimed to prepare and characterize lipid carrier systems, such as Solid Lipid Nanoparticles (SLN) and Nanostructured Lipid Carriers (NLC), as well as evaluate the potential of cyto and genotoxicity of these systems in order to improve and produce alternatives to the use targeting these compounds in veterinary applications. Lipid nanoparticles had become spherical with an average size of 250 nm and remained stable over 120 days. The encapsulation efficiency was greater than 99% for both drugs and release tests showed a strong interaction between drugs and nanoparticles. Cyto- and genotoxicity tests show that nanoparticles made possible changes in cellular viability of the tested cells. Thus, the results showed that the nanoparticles had good colloidal characteristics without changes in its characteristics, enabling the development of carrier systems for these drugs , aiming veterinary applications. (AU)

• FAPESP's process: 15/15617-9 - Botanical repellents and nanotechnology: development of systems for pest control in agriculture
• Grantee: Leonardo Fernandes Fraceto
• Support Opportunities: Regular Research Grants
• FAPESP's process: 13/24788-6 - Lipidic nanoparticles as carrier systems for ivermectin and methoprene aiming veterinary applications
• Grantee: Diego Faria Cola
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 13/12322-2 - Nanoparticles as carrier systems for bioactive compounds aiming agriculture applications
• Grantee: Leonardo Fernandes Fraceto
• Support Opportunities: Regular Research Grants