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Nanoparticles as carrier systems for bioactive compounds aiming agriculture applications

Grant number: 13/12322-2
Support type:Regular Research Grants
Duration: November 01, 2013 - October 31, 2015
Field of knowledge:Biological Sciences - Biochemistry - Chemistry of Macromolecules
Principal Investigator:Leonardo Fernandes Fraceto
Grantee:Leonardo Fernandes Fraceto
Home Institution: Universidade Estadual Paulista (UNESP). Campus Experimental de Sorocaba. Sorocaba , SP, Brazil
Assoc. researchers:Renata de Lima


The agricultural production systems employ large numbers of compounds for applications in agriculture in order to increase the quantity and quality of products. Brazil has become one of the largest consumers of these compounds in the world and, although they have an important role in agricultural productivity, these compounds are present in alarming amounts in surface water bodies and groundwater. Although they have an important role in agricultural productivity through minimizing pest activity and stimulate the growth of plants, they can create serious environmental impacts. In this context, different mechanisms are being studied in order to minimize these problems, for example, the development of sustained release systems using nanoparticles, which allows an increase in performance/efficiency of bioactive compounds. Therefore, this project aims at the development of new delivery systems for herbicides, fungicides and growth hormones used globally, so as to minimize the impacts of these on the environment, increase efficiency herbicide/antifungal and increased plant growth and fruits in order to reduce degradation processes in physico-chemical environment and improve the effect on target organisms. In this context, besides the development of new formulations for sustained release of herbicide/fungicide/growth hormones, also intend to study the stability of formulations, the nanotoxicological aspects and interaction with humic substances and soils matrix in order to find formulations that minimize impacts in the environment and humans. The importance of this project lies in the dimension of market bioactive compounds used in agriculture in the Brazilian economy and the world. Thus, the area of nanotechnology has potential in research and development of new technologies producing low impact on the environment and therefore to society. (AU)

Scientific publications (13)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MORENO, ADRIAN; JORDANA, AXEL; GRILLO, RENATO; FRACETO, LEONARDO F.; JAIME, CARLOS. A study on the molecular existing interactions in nanoherbicides: A chitooligosaccharide/tripolyphosphate loaded with paraquat case. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, v. 562, p. 220-228, FEB 5 2019. Web of Science Citations: 0.
NAKASATO, DANIELE Y.; PEREIRA, ANDERSON E. S.; OLIVEIRA, JHONES L.; OLIVEIRA, HALLEY C.; FRACETO, LEONARDO F. Evaluation of the effects of polymeric chitosan/tripolyphosphate and solid lipid nanoparticles on germination of Zea mays, Brassica rapa and Pisum sativum. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, v. 142, p. 369-374, AUG 2017. Web of Science Citations: 10.
MADUREIRA TAVARES, ERALDO JOSE; DE ARAUJO, DANIELE RIBEIRO; FRACETO, LEONARDO FERNANDES. Ivermectin-Loaded Polymeric Nanoparticles: Screening the Effects of Polymers, Methods, and the Usefulness of Mathematical Models. Journal of Nanoscience and Nanotechnology, v. 17, n. 6, p. 4218-4234, JUN 2017. Web of Science Citations: 1.
PEREIRA, A. E. S.; SANDOVAL-HERRERA, I. E.; ZAVALA-BETANCOURT, S. A.; OLIVEIRA, H. C.; LEDEZMA-PEREZ, A. S.; ROMERO, J.; FRACETO, L. F. gamma-Polyglutamic acid/chitosan nanoparticles for the plant growth regulator gibberellic acid: Characterization and evaluation of biological activity. Carbohydrate Polymers, v. 157, p. 1862-1873, FEB 10 2017. Web of Science Citations: 18.
CAMPOS, ESTEFANIA V. R.; DE OLIVEIRA, JHONES L.; PASCOLI, MONICA; DE LIMA, RENATE; FRACETO, LEONARDO F. Neem Oil and Crop Protection: From Now to the Future. FRONTIERS IN PLANT SCIENCE, v. 7, OCT 13 2016. Web of Science Citations: 16.
OLIVEIRA, HALLEY C.; STOLF-MOREIRA, RENATA; MARTINEZ, CLAUDIA B. R.; SOUSA, GUSTAVO F. M.; GRILLO, RENATO; DE JESUS, MARCELO B.; FRACETO, LEONARDO F. Evaluation of the side effects of poly(epsilon-caprolactone) nanocapsules containing atrazine toward maize plants. FRONTIERS IN CHEMISTRY, v. 3, OCT 21 2015. Web of Science Citations: 11.
RAMOS CAMPOS, ESTEFANIA VANGELIE; DE OLIVEIRA, JHONES LUIZ; GONCALVES DA SILVA, CAMILA MORAIS; PASCOLI, MONICA; PASQUOTO, TATIANE; LIMA, RENATA; ABHILASH, P. C.; FRACETO, LEONARDO FERNANDES. Polymeric and Solid Lipid Nanoparticles for Sustained Release of Carbendazim and Tebuconazole in Agricultural Applications. SCIENTIFIC REPORTS, v. 5, SEP 8 2015. Web of Science Citations: 34.
OLIVEIRA, HALLEY CAIXETA; STOLF-MOREIRA, RENATA; REIS MARTINEZ, CLAUDIA BUENO; GRILLO, RENATO; DE JESUS, MARCELO BISPO; FRACETO, LEONARDO FERNANDES. Nanoencapsulation Enhances the Post-Emergence Herbicidal Activity of Atrazine against Mustard Plants. PLoS One, v. 10, n. 7 JUL 17 2015. Web of Science Citations: 22.
GRILLO, RENATO; CLEMENTE, ZAIRA; DE OLIVEIRA, JHONES LUIS; RAMOS CAMPOS, ESTEFANIA VANGELIE; CHALUPE, VICTOR C.; JONSSON, CLAUDIO M.; DE LIMA, RENATA; SANCHES, GABRIELA; NISHISAKA, CAROLINE S.; ROSA, ANDRE H.; OEHLKE, KATHLEEN; GREINER, RALF; FRACETO, LEONARDO F. Chitosan nanoparticles loaded the herbicide paraquat: The influence of the aquatic humic substances on the colloidal stability and toxicity. JOURNAL OF HAZARDOUS MATERIALS, v. 286, p. 562-572, APR 9 2015. Web of Science Citations: 17.
GRILLO, RENATO; ROSA, ANDRE H.; FRACETO, LEONARDO F. Engineered nanoparticles and organic matter: A review of the state-of-the-art. Chemosphere, v. 119, p. 608-619, JAN 2015. Web of Science Citations: 128.
DE OLIVEIRA, JHONES LUIZ; RAMOS CAMPOS, ESTEFANIA VANGELIE; BAKSHI, MANSI; ABHILASH, P. C.; FRACETO, LEONARDO FERNANDES. Application of nanotechnology for the encapsulation of botanical insecticides for sustainable agriculture: Prospects and promises. BIOTECHNOLOGY ADVANCES, v. 32, n. 8, p. 1550-1561, DEC 2014. Web of Science Citations: 86.
GRILLO, RENATO; PEREIRA, ANDERSON E. S.; NISHISAKA, CAROLINE S.; DE LIMA, RENATA; OEHLKE, KATHLEEN; GREINER, RALF; FRACETO, LEONARDO F. Chitosan/tripolyphosphate nanoparticles loaded with paraquat herbicide: An environmentally safer alternative for weed control. JOURNAL OF HAZARDOUS MATERIALS, v. 278, p. 163-171, AUG 15 2014. Web of Science Citations: 71.

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