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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

HLA-DQA1/B1 alleles as putative susceptibility markers in congenital toxoplasmosis

Full text
Author(s):
Shimokawa, Paulo Tadashi ; Targa, Lilia Spaleta ; Yamamoto, Lidia ; Rodrigues, Jonatas Cristian ; Kanunfre, Kelly Aparecida ; Okay, Thelma Suely
Total Authors: 6
Document type: Journal article
Source: VIRULENCE; v. 7, n. 4, p. 456-464, 2016.
Web of Science Citations: 2
Abstract

Host and parasite genotypes are among the factors associated with congenital toxoplasmosis pathogenesis. As HLA class II molecules play a key role in the immune system regulation, the aim of this study was to investigate whether HLA-DQA1/B1 alleles are associated with susceptibility or protection to congenital toxoplasmosis. One hundred and twenty-two fetuses with and 103 without toxoplasmosis were studied. The two study groups were comparable according to a number of socio-demographic and genetic variables. HLA alleles were typed by PCR-SSP. In the HLA-DQA1 region, the allele frequencies showed that {*}01:03 and {*}03:02 alleles could confer susceptibility ( OR= 3.06, p = 0.0002 and OR=9.60, p= 0.0001, respectively) as they were more frequent among infected fetuses. Regarding the HLA-DQB1 region, the {*}05: 04 allele could confer susceptibility ( OR = 6.95, p < 0.0001). Of the 122 infected fetuses, 10 presented susceptibility haplotypes contrasting with only one in the non-infected group. This difference was not statistically significant after correction for multiple comparison ( OR = 9.37, p=0.011). In the casuistic, there were two severely damaged fetuses with high parasite loads determined in amniotic fluid samples and HLA-DQA1 susceptibility alleles. In the present study, a discriminatory potential of HLA-DQA1/B1 alleles to identify susceptibility to congenital toxoplasmosis and the most severe cases has been shown. (AU)

FAPESP's process: 10/15022-1 - Frequency of HLA-DQA1 and DQB1 alleles in fetuses with toxoplasmosis: association with the parasite genotype and the parasite load
Grantee:Thelma Suely Okay
Support Opportunities: Regular Research Grants