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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Antimicrobial peptides in saliva of children with severe early childhood caries

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Author(s):
Colombo, Natalia H. ; Ribas, Lais F. F. ; Pereira, Jesse A. ; Kreling, Paula F. ; Kressirer, Christine A. ; Tanner, Anne C. R. ; Duque, Cristiane
Total Authors: 7
Document type: Journal article
Source: ARCHIVES OF ORAL BIOLOGY; v. 69, p. 40-46, SEP 2016.
Web of Science Citations: 12
Abstract

Objective: Controversies exist regarding the relationship between the concentrations of antimicrobial peptides (AMPs) and presence of dental caries in children. Thus, the aim of this study was to examine levels of AMPs in saliva of caries-free (CF), early childhood caries (ECC) and severe early childhood caries (S-ECC) children to determine if the levels of these salivary peptides individually or in combinations were related to caries severity and mutans streptococci levels. Design: 36 to 60 month-old children were selected to participate in this study. Children were grouped into CF group (n = 29), ECC group (n = 25) and S-ECC group (n = 29). Saliva was collected from children for microbiological analysis by culture. Salivary concentrations of cathelicidin LL-37, human beta-defensin 2 (hBD-2), human beta-defensin 3 (hBD-3) and histatin-5 (HTN-5) were determined by ELISA. Results: Salivary concentrations of AMPs did not differ among CF, ECC and S-ECC groups. Data showed positive correlations between mutans streptococci levels and salivary hBD-2 or HTN-5. Positive correlations were found between hBD-2, hBD-3, LL-37 and HTN-5. Combinations among AMPs, mainly LL-37, were positively associated with caries levels. Conclusions: Salivary concentrations of AMPs individually were not associated with the severity of early childhood caries. The stimulus of caries appears to trigger a biological response, however, with a combination of these peptides. (C) 2016 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 13/12167-7 - Influence of environmental factors, levels of potentially cariogenic microorganisms and antimicrobial peptides on the development of early childhood caries
Grantee:Lais Fernanda Fonseca Ribas
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 12/19235-5 - Antimicrobial and immunological role of cationic peptides in the prevention of early childhood caries and a proposal for incorporation of these peptides in nanoparticles systems as anticaries agents
Grantee:Cristiane Duque
Support Opportunities: Regular Research Grants