| Full text | |
| Author(s): |
Jockers, Ralf
;
Delagrange, Philippe
;
Dubocovich, Margarita L.
;
Markus, Regina P.
;
Renault, Nicolas
;
Tosini, Gianluca
;
Cecon, Erika
;
Zlotos, Darius P.
Total Authors: 8
|
| Document type: | Review article |
| Source: | British Journal of Pharmacology; v. 173, n. 18, p. 2702-2725, SEP 2016. |
| Web of Science Citations: | 70 |
| Abstract | |
Melatonin receptors are seven transmembrane-spanning proteins belonging to the GPCR superfamily. In mammals, two melatonin receptor subtypes exist - MT1 and MT2 - encoded by the MTNR1A and MTNR1B genes respectively. The current review provides an update on melatonin receptors by the corresponding subcommittee of the International Union of Basic and Clinical Pharmacology. We will highlight recent developments of melatonin receptor ligands, including radioligands, and give an update on the latest phenotyping results of melatonin receptor knockout mice. The current status and perspectives of the structure of melatonin receptor will be summarized. The physiological importance of melatonin receptor dimers and biologically important and type 2 diabetes-associated genetic variants of melatonin receptors will be discussed. The role of melatonin receptors in physiology and disease will be further exemplified by their functions in the immune system and the CNS. Finally, antioxidant and free radical scavenger properties of melatonin and its relation to melatonin receptors will be critically addressed. (AU) | |
| FAPESP's process: | 13/13691-1 - Immune-pineal axis: time-niology integrated to surveillance and defense |
| Grantee: | Regina Pekelmann Markus |
| Support Opportunities: | Research Projects - Thematic Grants |