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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Role of central hydrogen sulfide on ventilatory and cardiovascular responses to hypoxia in spontaneous hypertensive rats

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Sabino, Joao Paulo J. ; Ariza Traslavina, Guillermo A. ; Branco, Luiz G. S.
Total Authors: 3
Document type: Journal article
Source: Respiratory Physiology & Neurobiology; v. 231, p. 21-27, SEP 2016.
Web of Science Citations: 4

Central hydrogen sulfide (H2S) has been reported to act as a gaseous neuromodulator involved in the ventilatory and cardiovascular control of normotensive rats, whereas no information is available in spontaneously hypertensive rats (SHR). We recorded minute ventilation (V-E), mean arterial pressure (MAP) and heart rate (HR) before and after blocking of enzyme Cystathionine beta-synthase (CBS) producing H2 S in neural tissue by microinjection of aminooxyacetate (inhibitor of CBS) into the fourth ventricle of Wistar normotensive rats (WNR) and SHR followed by 30 min of normoxia (21% inspired O-2) or hypoxia (10% inspired O-2) exposure. Microinjection of AOA or saline (1 mu L) did not change V-E, MAP and HR during normoxia in both WNR and SHR. In WNR, hypoxia caused an increase in V-E, HR and a decrease in MAP and these responses were unaltered by AOA. In SHR, hypoxia produced a higher increase of V-E, and decrease in MAP and HR when compared to WNR, and these responses were all blunted by AOA. In conclusion, endogenous H2S plays important modulatory roles on hypoxia-induced ventilatory and cardiovascular responses, inhibiting the cardiovascular and stimulating the respiratory systems in SHR. (C) 2016 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 11/14779-4 - Effect of hydrogen sulfide (H2S) in the commissural NTS on the ventilatory and hemodynamic response to hypoxia and hypercapnia in normotensive and hypertensive animals
Grantee:João Paulo Jacob Sabino
Support type: Scholarships in Brazil - Post-Doctorate