Role of central hydrogen sulfide on ventilatory and cardiovascular responses to hypoxia in spontaneous hypertensive rats

Author(s)

Sabino, Joao Paulo J. ; Ariza Traslavina, Guillermo A. ; Branco, Luiz G. S.

• Document type: Journal article
• Source: Respiratory Physiology & Neurobiology; v. 231, p. 21-27, SEP 2016.
• Web of Science Citations: 4

Abstract

Central hydrogen sulfide (H2S) has been reported to act as a gaseous neuromodulator involved in the ventilatory and cardiovascular control of normotensive rats, whereas no information is available in spontaneously hypertensive rats (SHR). We recorded minute ventilation (V-E), mean arterial pressure (MAP) and heart rate (HR) before and after blocking of enzyme Cystathionine beta-synthase (CBS) producing H2 S in neural tissue by microinjection of aminooxyacetate (inhibitor of CBS) into the fourth ventricle of Wistar normotensive rats (WNR) and SHR followed by 30 min of normoxia (21% inspired O-2) or hypoxia (10% inspired O-2) exposure. Microinjection of AOA or saline (1 mu L) did not change V-E, MAP and HR during normoxia in both WNR and SHR. In WNR, hypoxia caused an increase in V-E, HR and a decrease in MAP and these responses were unaltered by AOA. In SHR, hypoxia produced a higher increase of V-E, and decrease in MAP and HR when compared to WNR, and these responses were all blunted by AOA. In conclusion, endogenous H2S plays important modulatory roles on hypoxia-induced ventilatory and cardiovascular responses, inhibiting the cardiovascular and stimulating the respiratory systems in SHR. (C) 2016 Elsevier B.V. All rights reserved. (AU)

• FAPESP's process: 11/14779-4 - Effect of hydrogen sulfide (H2S) in the commissural NTS on the ventilatory and hemodynamic response to hypoxia and hypercapnia in normotensive and hypertensive animals
• Grantee: João Paulo Jacob Sabino
• Support type: Scholarships in Brazil - Post-Doctorate