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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Accessing the biocompatibility of layered double hydroxide by intramuscular implantation: histological and microcirculation evaluation

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Rodrigues Cunha, Vanessa Roberta ; de Souza, Rodrigo Barbosa ; Pinto da Fonseca Martins, Ana Maria Cristina Rebello ; Jun Koh, Ivan Hong ; Leopoldo Constantino, Vera Regina
Total Authors: 5
Document type: Journal article
Source: SCIENTIFIC REPORTS; v. 6, AUG 2 2016.
Web of Science Citations: 20

Biocompatibility of layered double hydroxides (LDHs), also known as hydrotalcite-like materials or double metal hydroxides, was investigated by in vivo assays via intramuscular tablets implantation in rat abdominal wall. The tablets were composed by chloride ions intercalated into LDH of magnesium/aluminum (Mg2Al-Cl) and zinc/aluminum (Zn2Al-Cl). The antigenicity and tissue integration capacity of LDHs were assessed histologically after 7 and 28 days post-implantation. No fibrous capsule nearby the LDH was noticed for both materials as well any sign of inflammatory reactions. Sidestream Dark Field imaging, used to monitor in real time the microcirculation in tissues, revealed overall integrity of the microcirculatory network neighboring the tablets, with no blood flow obstruction, bleeding and/or increasing of leukocyte endothelial adhesion. After 28 days Mg2Al-Cl promoted multiple collagen invaginations (mostly collagen type-I) among its fragments while Zn2Al-Cl induced predominantly collagen type-III. This work supports previous results in the literature about LDHs compatibility with living matter, endorsing them as functional materials for biomedical applications. (AU)

FAPESP's process: 11/50318-1 - Development of compounds with pharmacological or medicinal interest and of systems for their transport, detection and recognition in biological media
Grantee:Ana Maria da Costa Ferreira
Support type: Research Projects - Thematic Grants
FAPESP's process: 12/12209-9 - Inorganic carriers of bioactive substances: development, characterization, toxicity evaluation of in vitro delivery and in vivo absorption after oral administration
Grantee:Vanessa Roberta Rodrigues da Cunha
Support type: Scholarships in Brazil - Post-Doctorate