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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Rutin increases critical wavelength of systems containing a single UV filter and with good skin compatibility

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Author(s):
Peres, D. A. ; de Oliveira, C. A. ; da Costa, M. S. ; Tokunaga, V. K. ; Mota, J. P. ; Rosado, C. ; Consiglieri, V. O. ; Kaneko, T. M. ; Velasco, M. V. R. ; Baby, A. R.
Total Authors: 10
Document type: Journal article
Source: SKIN RESEARCH AND TECHNOLOGY; v. 22, n. 3, p. 325-333, AUG 2016.
Web of Science Citations: 7
Abstract

Background/purpose: Ultraviolet (UV) radiation is responsible for sunburns, skin cancer, photoaging, and the production of reactive oxygen species (ROS). The awareness on preventing these deleterious effects made the use of anti-UVB formulations an important part of population habits; however, despite the availability of several antioxidants capable of ROS scavenging, the pharmaceutical market lacks products associating UV filters with natural compounds of proven efficacy. Here, we investigated the effect of rutin, a flavonoid with antioxidant activity, associated with UVB filters in dermocosmetic preparations. Methods: Formulations were assessed through its antioxidant activity, in vitro photoprotective effectiveness, photostability, and in vivo skin tolerance (hydration, transepidermal water loss, and erythema). Results: Samples containing rutin were compatible with the human skin and presented a pronounced antioxidant potential, with scavenging activity values 75% higher than the ones containing only UVB filters. Although rutin could not prevent the sunscreens photodegradation post-irradiation, the bioactive compound significantly increased the formulations critical wavelengths, showing a photoprotective gain, especially in the UVA range. Conclusion: In conclusion, the absorption in the UVA range, coupled with ROS scavenging potential, proved the positive effect of rutin applied to anti-UVB formulations, making this bioactive compound a promising candidate for photoprotection improvement. (AU)

FAPESP's process: 08/57800-0 - Broad-spectrum sunscreens: conceptual and practical development of bioactive sunscreens
Grantee:André Rolim Baby
Support Opportunities: Regular Research Grants
FAPESP's process: 10/10739-5 - Rutin for application in sunscreens: electronic interaction with UV filters, antioxidant activity and "in vitro" efficacy
Grantee:André Rolim Baby
Support Opportunities: Regular Research Grants