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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The Expression of the Androgen Receptor and Estrogen Receptor 1 is Related to Sex Dimorphism in the Gerbil Prostate Development

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Author(s):
Sanches, Bruno D. A. ; Maldarine, Juliana S. ; Zani, Bruno C. ; Biancardi, Manoel F. ; Santos, Fernanda C. A. ; Goes, Rejane M. ; Vilamaior, Patricia S. L. ; Taboga, Sebastiao R.
Total Authors: 8
Document type: Journal article
Source: Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology; v. 299, n. 8, p. 1130-1139, AUG 2016.
Web of Science Citations: 2
Abstract

The development of the prostate gland in females has not yet been clearly elucidated, and the sexual dimorphism associated with such gland development in general is far from being understood. In the present study, we used tridimensional (3D) reconstructions and histochemical and immunohistochemical techniques to describe the sexual dimorphism and its causes in the early postnatal development of the prostate in male and female Mongolian gerbils (Meriones unguiculatus). We observed that the female prostate was smaller, had fewer branches throughout the development, and underwent differentiation earlier than that in males. Also, the expression of the estrogen receptor 1 (ESR1 or ER-alpha) and fibroblast growth factor 10 (FGF10) was decreased in the periductal region, and the expression of the androgen receptor (AR) was increased in the epithelium. All together, these changes decreased proliferation and branching and led to an earlier prematuration of the female prostate. These new data shed light on the underlying mechanisms involved with the sexual dimorphism in the development of the prostate. Anat Rec, 299:1130-1139, 2016. (C) 2016 Wiley Periodicals, Inc. (AU)

FAPESP's process: 13/15939-0 - Evaluation of intrauterine oestrogenic exposure on the main epithelium-mesenchyme interaction pathways in the branching morphogenesis in the Mongolian Gerbil prostrate ventral lobe
Grantee:Bruno Domingos Azevedo Sanches
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 13/16443-9 - Descriptive study of the branching process of Mongolian gerbil (Meriones unguiculatus) prostate ventral lobe
Grantee:Bruno Casagrande Zani
Support Opportunities: Scholarships in Brazil - Scientific Initiation