| Full text | |
| Author(s): |
Tizioto, P. C.
;
Coutinho, L. L.
;
Mourao, G. B.
;
Gasparin, G.
;
Malago-, Jr., W.
;
Bressani, F. A.
;
Tullio, R. R.
;
Nassu, R. T.
;
Taylor, J. F.
;
Regitano, L. C. A.
Total Authors: 10
|
| Document type: | Journal article |
| Source: | ANIMAL GENETICS; v. 47, n. 4, p. 491-494, AUG 2016. |
| Web of Science Citations: | 0 |
| Abstract | |
The myogenic differentiation 1 gene (MYOD1) has a key role in skeletal muscle differentiation and composition through its regulation of the expression of several muscle-specific genes. We first used a general linear mixed model approach to evaluate the association of MYOD1 expression levels on individual beef tenderness phenotypes. MYOD1mRNA levels measured by quantitative polymerase chain reactions in 136 Nelore steers were significantly associated (P0.01) with Warner-Bratzler shear force, measured on the longissimus dorsi muscle after 7 and 14days of beef aging. Transcript abundance for the muscle regulatory gene MYOD1 was lower in animals with more tender beef. We also performed a co-expression network analysis using whole transcriptome sequence data generated from 30 samples of longissimus muscle tissue to identify genes that are potentially regulated by MYOD1. The effect of MYOD1 gene expression on beef tenderness may emerge from its function as an activator of muscle-specific gene transcription such as for the serum response factor (C-fos serum response element-binding transcription factor) gene (SRF), which determines muscle tissue development, composition, growth and maturation. (AU) | |
| FAPESP's process: | 10/06515-4 - Prospection and validation of SNPs in candidate genes for meat tenderness in reference families of Nellore breed |
| Grantee: | Polyana Cristine Tizioto |
| Support Opportunities: | Scholarships in Brazil - Doctorate |