Amphetamine and derivatives in natural weight loss pills and dietary supplements by capillary electrophoresis-tandem mass spectrometry

Author(s)

dos Santos, Vagner Bezerra ; Daniel, Daniela ; Singh, Melina ; do Lago, Claudimir Lucio

• Document type: Journal article
• Source: JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES; v. 1038, p. 19-25, DEC 1 2016.
• Web of Science Citations: 6

Abstract

A capillary electrophoresis-tandem mass spectrometry (CE-MS/MS) method for amphetamine (AM), phentermine (PTM), methamphetamine (MAM), methylenedioxyamphetamine (MDA), methylenedioxymethamphetamine (MDMA), and methylenedioxyethylamphetamine (MDEA) in commercial samples of homeopathic and phytotherapic medicines and dietary supplements is presented. The samples were submitted to a modified QuEChERS extraction procedure (at apparent pH 13) followed by electrophoretic separation in 0.1 mol L-1 formic acid electrolyte (pH 2.4) and detection by ESI-MS/MS. A polyvinyl alcohol coated capillary was employed to prevent the adsorption of the analytes to the capillary wall. The limits of detection and quantitation were from 0.02 to 0.06 mu z L-1 and from 0.06 to 0.21 mu g L-1, respectively, with recovery ranging from 85 to 123% and the standard deviations were not greater than 6.1%. In addition, the separation occurs in less than six minutes. (C) 2016 Elsevier B.V. All rights reserved. (AU)

• FAPESP's process: 13/14993-1 - Characterization and quantification of monoalkyl carbonates in aqueous medium employing microfluidic devices coupled to a mass spectrometer
• Grantee: Vagner Bezerra dos Santos
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 12/06642-1 - Formation and properties of adducts of organic hydroxy-compounds with carbonate in aqueous medium and biological conditions
• Grantee: Claudimir Lucio Do Lago
• Support Opportunities: Regular Research Grants