Formation and properties of adducts of organic hydroxy-compounds with carbonate in aqueous medium and biological conditions

• Grant number: 12/06642-1
• Support type: Regular Research Grants
• Duration: August 01, 2012 - July 31, 2014
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
• Principal Investigator: Claudimir Lucio Do Lago
• Grantee: Claudimir Lucio Do Lago
• Home Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The formation of monoalkyl carbonates (MACs) from carbon dioxide or bicarbonate and alcohols in aqueous medium has been shown in recent works. Among these MACs, those ones from aliphatic alcohols and sugars have been of particular interest for our group. Many metabolites may be included in one of these classes, or they have part of their molecular structure whose reactivity is governed by such groups. Thus, the present proposal is to study the formation and the properties of MACs with possible biological roles. Up until now, we have used capillary electrophoresis with capacitively coupled contactless conductivity detection (CE-C4D) as the main technique. The idea is to include electrospray ionization-mass spectrometry as an alternative technique, as well as in its hyphenated form with electrophoresis. We hope to be able to answer some questions about the formation and the properties of fatty MACs and mono- and disaccharides, as well as about the catalytic effect of some carbonic anhydrases on the interconversion between bicarbonate and MACs. (AU)

Scientific publications

(24)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DANIEL, DANIELA; LOPES, FERNANDO SILVA; DO LAGO, CLAUDIMIR LUCIO. A sensitive multiresidue method for the determination of pesticides in marijuana by liquid chromatography-tandem mass spectrometry. Journal of Chromatography A, v. 1603, p. 231-239, OCT 2019. Web of Science Citations: 1.

FERREIRA SANTOS, MAURO SERGIO; CORDEIRO, THIAGO GOMES; CIESLAROVA, ZUZANA; ROLF GUTZ, IVANO GEBHARDT; GARCIA, CARLOS D. Photochemical and photocatalytic degradation of 1-propanol using UV/H2O2: Identification of malonate as byproduct. ELECTROPHORESIS, v. 40, n. 18-19, p. 2256-2262, SEP 2019. Web of Science Citations: 1.

DANIEL, DANIELA; DO LAGO, CLAUDIMIR LUCIO. Determination of Multiclass Pesticides Residues in Corn by QuEChERS and Capillary Electrophoresis Tandem Mass Spectrometry. FOOD ANALYTICAL METHODS, v. 12, n. 7, p. 1684-1692, JUL 2019. Web of Science Citations: 0.

MENDES, LETICIA FRANCINE; SOUZA E SILVA, ANGELA RODRIGUES; BACIL, RAPHAEL PRATA; PIRES SERRANO, SILVIA HELENA; ANGNES, LUCIO; LONGO CESAR PAIXAO, THIAGO REGIS; DE ARAUJO, WILLIAM REIS. Forensic electrochemistry: Electrochemical study and quantification of xylazine in pharmaceutical and urine samples. Electrochimica Acta, v. 295, p. 726-734, FEB 1 2019. Web of Science Citations: 1.

CIESLAROVA, ZUZANA; MAGALDI, MARIANA; BARROS, LUCELIA ALCANTARA; DO LAGO, CLAUDIMIR LUCIO; OLIVEIRA, DANIEL ROSSADO; HELFENSTEIN FONSECA, FRANCISCO ANTONIO; IZAR, MARIA CRISTINA; LOPES, ALINE SORIANO; MAGGI TAVARES, MARINA FRANCO; KLASSEN, ALINE. Capillary electrophoresis with dual diode array detection and tandem mass spectrometry to access cardiovascular biomarkers candidates in human urine: Trimethylamine-N-Oxide and L-carnitine. Journal of Chromatography A, v. 1583, p. 136-142, JAN 4 2019. Web of Science Citations: 4.

SILVA, GABRIEL GONCALVES; DE ALMEIDA, EIJI YAMASSAKI; SEBER, PEDRO; SETTANNI, PEDRO HENRIQUE; DE OLIVEIRA, ALINE PEREIRA; FERREIRA SANTOS, MAURO SERGIO; DO LAGO, CLAUDIMIR LUCIO; CIESLAROVA, ZUZANA; RODRIGUES, FABIO. Application of capillary electrophoresis combined with conductometric and UV detection to monitor meteorite simulant bioleaching by Acidithiobacillus ferrooxidans. ELECTROPHORESIS, v. 39, n. 22, SI, p. 2898-2905, NOV 2018. Web of Science Citations: 0.

CIESLAROVA, ZUZANA; DOS SANTOS, VAGNER BEZERRA; DO LAGO, CLAUDIMIR LUCIO. Both carbamates and monoalkyl carbonates are involved in carbon dioxide capture by alkanolamines. INTERNATIONAL JOURNAL OF GREENHOUSE GAS CONTROL, v. 76, p. 142-149, SEP 2018. Web of Science Citations: 1.

MENDONCA FRANCISCO, KELLITON JOSE; DO LAGO, CLAUDIMIR LUCIO. Improving thermal control of capillary electrophoresis with mass spectrometry and capacitively coupled contactless conductivity detection by using 3D printed cartridges. Talanta, v. 185, p. 37-41, AUG 1 2018. Web of Science Citations: 1.

DANIEL, DANIELA; LOPES, FERNANDO SILVA; DOS SANTOS, VAGNER BEZERRA; DO LAGO, CLAUDIMIR LUCIO. Detection of coffee adulteration with soybean and corn by capillary electrophoresis-tandem mass spectrometry. Food Chemistry, v. 243, p. 305-310, MAR 15 2018. Web of Science Citations: 9.

REIS TEIXEIRA, WANDERSON SIRLEY; FERREIRA SANTOS, MAURO SERGIO; GRUBER, JONAS; ROLF GUTZ, IVANO GEBHARDT; LOPES, FERNANDO SILVA. Determination of neutral diols and carboxylic acids formed during glycerol electrooxidation by capillary electrophoresis with dual (CD)-D-4. Talanta, v. 178, p. 1040-1045, FEB 1 2018. Web of Science Citations: 5.

GUIMARAES SELVA, THIAGO MATHEUS; DE ARAUJO, WILLIAM REIS; BACIL, RAPHAEL PRATA; LONGO CESAR PAIXAO, THIAGO REGIS. Study of Electrochemical Oxidation and Quantification of the Pesticide Pirimicarb Using a Boron-Doped Diamond Electrode. Electrochimica Acta, v. 246, p. 588-596, AUG 20 2017. Web of Science Citations: 9.

CIESLAROVA, ZUZANA; LOPES, FERNANDO SILVA; DO LAGO, CLAUDIMIR LUCIO; FRANCA, JR., MARCONDES CAVALCANTE; COLNAGHI SIMIONATO, ANA VALERIA. Capillary electrophoresis tandem mass spectrometry determination of glutamic acid and homocysteine's metabolites: Potential biomarkers of amyotrophic lateral sclerosis. Talanta, v. 170, p. 63-68, AUG 1 2017. Web of Science Citations: 10.

DOS SANTOS, VAGNER BEZERRA; DANIEL, DANIELA; SINGH, MELINA; DO LAGO, CLAUDIMIR LUCIO. Amphetamine and derivatives in natural weight loss pills and dietary supplements by capillary electrophoresis-tandem mass spectrometry. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, v. 1038, p. 19-25, DEC 1 2016. Web of Science Citations: 6.

MONTES, RODRIGO H. O.; LIMA, ANA P.; DOS SANTOS, VAGNER B.; VIDAL, DENIS T. R.; DO LAGO, CLAUDIMIR L.; RICHTER, EDUARDO M.; MUNOZ, RODRIGO A. A. Carbon-nanotube amperometric sensor for selective determination of 4-chloroaniline in commercial chlorhexidine solutions. SENSORS AND ACTUATORS B-CHEMICAL, v. 231, p. 38-44, AUG 2016. Web of Science Citations: 5.

MENDONCA FRANCISCO, KELLITON JOSE; DO LAGO, CLAUDIMIR LUCIO. A capillary electrophoresis system with dual capacitively coupled contactless conductivity detection and electrospray ionization tandem mass spectrometry. ELECTROPHORESIS, v. 37, n. 12, p. 1718-1724, JUL 2016. Web of Science Citations: 10.

DOS SANTOS, VAGNER B.; VIDAL, DENIS T. R.; FRANCISCO, KELLITON J. M.; DUCATI, LUCAS C.; DO LAGO, CLAUDIMIR L. Formation of isomers of anionic hemiesters of sugars and carbonic acid in aqueous medium. Carbohydrate Research, v. 428, p. 18-22, JUN 16 2016. Web of Science Citations: 3.

DANIEL, DANIELA; DOS SANTOS, VAGNER BEZERRA; RAJH VIDAL, DENIS TADEU; DO LAGO, CLAUDIMIR LUCIO. Determination of biogenic amines in beer and wine by capillary electrophoresis-tandem mass spectrometry. Journal of Chromatography A, v. 1416, p. 121-128, OCT 16 2015. Web of Science Citations: 49.

DANIEL, DANIELA; DOS SANTOS, VAGNER BEZERRA; RAJH VIDAL, DENIS TADEU; DO LAGO, CLAUDIMIR LUCIO. Determination of halosulfuron-methyl herbicide in sugarcane juice and tomato by capillary electrophoresis-tandem mass spectrometry. Food Chemistry, v. 175, p. 82-84, MAY 15 2015. Web of Science Citations: 16.

DO LAGO, CLAUDIMIR LUCIO; RAJH VIDAL, DENIS TADEU; MENDONCA FRANCISCO, KELLITON JOSE; DOS SANTOS, VAGNER BEZERRA. A simple approach to compensate the suction caused by the electrospray ionization source in capillary electrophoresis-mass spectrometry systems. ELECTROPHORESIS, v. 35, n. 16, SI, p. 2412-2416, AUG 2014. Web of Science Citations: 7.

MARRA, MARIANA CARDOSO; CUNHA, RAFAEL RODRIGUES; RAJH VIDAL, DENIS TADEU; ABARZA MUNOZ, RODRIGO ALEJANDRO; DO LAGO, CLAUDIMIR LUCIO; RICHTER, EDUARDO MATHIAS. Ultra-fast determination of caffeine, dipyrone, and acetylsalicylic acid by capillary electrophoresis with capacitively coupled contactless conductivity detection and identification of degradation products. Journal of Chromatography A, v. 1327, p. 149-154, JAN 31 2014. Web of Science Citations: 27.

DO LAGO, CLAUDIMIR LUCIO; MENDONA FRANCISCO, KELLITON JOSE; DANIEL, DANIELA; RAJH VIDAL, DENIS TADEU; DOS SANTOS, VAGNER BEZERRA. A capillary electrophoresis/tandem mass spectrometry approach for the determination of monoalkyl carbonates. RSC ADVANCES, v. 4, n. 38, p. 19674-19679, 2014. Web of Science Citations: 4.

VIDAL, DENIS T. R.; DO LAGO, CLAUDIMIR L. Capillary electrophoresis with capacitively coupled contactless conductivity detection applied to the quantitation and to the determination of physical-chemical properties of peroxycarboxylates in aqueous medium. ELECTROPHORESIS, v. 34, n. 14, SI, p. 2065-2071, JUL 2013. Web of Science Citations: 6.

RAJH VIDAL, DENIS TADEU; AUGELLI, MARCIO ANTONIO; DO LAGO, CLAUDIMIR LUCIO. Determination of sildenafil and vardenafil by capillary zone electrophoresis using capacitively coupled contactless conductivity detection. ANALYTICAL METHODS, v. 5, n. 8, p. 2041-2045, 2013. Web of Science Citations: 7.

RAJH VIDAL, DENIS TADEU; SANTANA, MICHELE ALVES; HOTTA, GUILHERME MINORU; GODOI, MARLA NARCISO; EBERLIN, MARCOS NOGUEIRA; DO LAGO, CLAUDIMIR LUCIO. Probing the formation of monoalkyl carbonates and pyrocarbonates in water with electrospray ionization mass spectrometry. RSC ADVANCES, v. 3, n. 41, p. 18886-18893, 2013. Web of Science Citations: 5.