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Study of the properties of the carbonate adducts of 1,3-butanediol and panthenol in aqueous medium.

Grant number: 12/15467-9
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): November 01, 2012
Effective date (End): October 31, 2014
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
Principal Investigator:Claudimir Lucio Do Lago
Grantee:Michele Alves Santana
Home Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Recently, we demonstrated that monoalkyl carbonates (MACs) can be formed in aqueous medium from carbon dioxide or bicarbonate and an alcohol. There is an increasing interest in this phenomenon, because of the likely presence and function in biological medium. In this sense, polyols are of particular interest. Thus, the present proposal aims the study of carbonate adducts formed with two prototype polyols: 1,3 butanediol and panthenol. Although both polyols are not involved in significant biological processes, they have hydroxyl groups with distinct characteristics, which can help in the elucidation of carbonate formation process. Capillary electrophoresis with capacitively coupled contactless conductivity detection will be used as a starting technique, which has been used in the previous studies. Mass spectrometry with electrospray ionization shall also be used in order to help in structural elucidation of the possible isomers.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
RAJH VIDAL, DENIS TADEU; SANTANA, MICHELE ALVES; HOTTA, GUILHERME MINORU; GODOI, MARLA NARCISO; EBERLIN, MARCOS NOGUEIRA; DO LAGO, CLAUDIMIR LUCIO. Probing the formation of monoalkyl carbonates and pyrocarbonates in water with electrospray ionization mass spectrometry. RSC ADVANCES, v. 3, n. 41, p. 18886-18893, 2013. Web of Science Citations: 5.

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