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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

New perylenequinone derivatives from the endophytic fungus Alternaria tenuissima SS77

Full text
Author(s):
Chagas, Fernanda O. ; Dias, Luis G. ; Pupo, Monica T.
Total Authors: 3
Document type: Journal article
Source: Tetrahedron Letters; v. 57, n. 29, p. 3185-3189, JUL 20 2016.
Web of Science Citations: 4
Abstract

Three new natural products, 1,4,6b,7,10-pentahydroxy-1,2,6b,7,8,12b-hexahydroperylene-3,9-dione (1), 1,4,9,12a-tetrahydroxy-12-methoxy-1,2,11,12,12a,12b-hexahydroperylene-3, 10-dione (2) and 1,4,9-tri-hydroxy-1,2-dihydroperylene-3,10-dione (3), were obtained from cultures of the endophytic fungus Alternaria tenuissima SS77. Their chemical structures were determined by combined analysis of one and two-dimensional NMR spectra, UV and ESIHRMS data. Compound 3 is likely an intermediate in the biosynthetic pathway of some perylenequinones produced by this fungus. A new hypothesis for the biosynthesis of partially reduced perylenequinones is suggested. (C) 2016 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 13/08166-5 - Interfacial chemistry: drugs, peptides and ezymes interactions with membrane models
Grantee:Iolanda Midea Cuccovia
Support type: Research Projects - Thematic Grants
FAPESP's process: 13/07600-3 - CIBFar - Center for Innovation in Biodiversity and Drug Discovery
Grantee:Glaucius Oliva
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 08/09540-0 - New strategies in the search of natural antibiotics: symbiotic microorganisms as sources of compounds and in vivo assay based on Caenorhabditis elegans infection model
Grantee:Mônica Tallarico Pupo
Support type: Regular Research Grants
FAPESP's process: 09/17695-6 - New strategies to access microbial natural products: mixed cultures of endophytes, chemical and epigenetic remodeling of biosynthetic pathways
Grantee:Fernanda Oliveira das Chagas
Support type: Scholarships in Brazil - Doctorate