Therapeutic potential evaluation of L-amino acid oxidases isolated from snake veno...
| Full text | |
| Author(s): |
Burin, Sandra Mara
;
Berzoti-Coelho, Maria Gabriela
;
Cominal, Jucara Gastaldi
;
Ambrosio, Luciana
;
Torqueti, Maria Regina
;
Sampaio, Suely Vilela
;
de Castro, Fabiola Attie
Total Authors: 7
|
| Document type: | Journal article |
| Source: | Toxicon; v. 120, p. 9-14, SEP 15 2016. |
| Web of Science Citations: | 10 |
| Abstract | |
Anti-apoptotic genes and apoptomiRs deregulated expression contribute to apoptosis resistance in chronic myeloid leukemia (CML) Bcr-Abl(+) cells. Here, the L-amino acid oxidase from Calloselasma rhodostoma (CR-LAAO) venom altered the apoptotic machinery regulation by modulating the expression of the miR-145, miR-26a, miR-142-3p, miR-21, miR-130a, and miR-146a, and of the apoptosis-related proteins Bid, Bim, Bcl-2, Ciap-2, c-Flip, and Mcl-1 in Bcr-Abl(+) cells. CR-LAAO is a potential tool to instigate apoptomiRs regulation that contributes to drive CML therapy. (C) 2016 Elsevier Ltd. All rights reserved. (AU) | |
| FAPESP's process: | 15/25637-7 - Epigenetic modulation of apoptotic machinery in Bcr-Abl positive cells by BmooLAAO-I and MjTX-I toxins |
| Grantee: | Sandra Mara Burin de Menezes |
| Support type: | Scholarships in Brazil - Post-Doctorate |
| FAPESP's process: | 15/23555-3 - Regulators microRNAs of Hippo pathway in chronic myeloid leukemia |
| Grantee: | Maria Gabriela Berzoti Coelho |
| Support type: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 11/23236-4 - Native and recombinant animal toxins: functional, structural and molecular analysis |
| Grantee: | Suely Vilela |
| Support type: | Research Projects - Thematic Grants |