| Full text | |
| Author(s): |
Mathews, Patrick D.
;
Mertins, Omar
Total Authors: 2
|
| Document type: | Journal article |
| Source: | Carbohydrate Polymers; v. 157, p. 850-857, FEB 10 2017. |
| Web of Science Citations: | 4 |
| Abstract | |
Bicontinuous cubic phases were produced with introduction of chitosan in phospholipid/water hydro gel, providing composites of defined molecular organization. The ratio of lipid/water was constant and swelling of lipids bilayer is delimited by incorporation of polymer molecules into the structure. By means of synchrotron small angle X-ray scattering we identified topologies of coexisting cubic phases. The expected liquid crystalline L-alpha, lamellar phase was suppressed by 0.2 wt% chitosan leading to formation of diamond Pn3m and gyroid la3d cubic topology, with close lattice distances. An increment to 0.4 wt% chitosan caused large increase in Pn3m lattice distance. However a higher 0.6 wt% evolved this phase to a newly acquired primitive Im3m topology. The structuring process of the three-dimensional complex network is principally governed by demands of chitosan physical requirements over lipids bilayers interfacial curvature. The composite hydrogel of specific topologies presents reduced time release of gallic acid and may find application as new material for time-sustained delivery of bioactive compounds. (C) 2016 Elsevier Ltd. All rights reserved. (AU) | |
| FAPESP's process: | 15/23948-5 - Improvement of the polysaccharide chitosan properties for its application in liposomes and giant vesicles |
| Grantee: | Omar Mertins |
| Support Opportunities: | Regular Research Grants |