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Scaffolds of biopolymers of natural, synthetic or composite origin will be produced and evaluated, aiming their application in the regeneration of the support alveolar bone. These biopolymers must form a three-dimensional, highly porous, resistant, resilient and bioadhesive framework. Scaffolds will be obtained from three-dimensional structured hydrogels with the possibility of being molded in lamellar, laminated, cylindrical, cubic, granulated and so on. Scaffolds will be designed for a bio-persistence of at least 90 days. To achieve this retention time, the formulations will be composed of cross-linked biopolymers capable of regulating biodegradation and maintaining physiological functions and stimulating the regeneration of bone tissue. The biopolymers to be used will be collagen type I (COL-I), silk fibroin (FS), bacterial nano-cellulose (nCB), chitosan (Qt), hyaluronic acid (HA) and sodium alginate (AS). Curcumin (CUR), due to its anticancer and antibacterial action, and hydroxyapatite (Hap) incorporation to the scaffolds will be tested to increase surface reactivity, expanding integration with the adjacent tissue stimulating adhesion, migration and proliferation, in addition to improving mechanical resistance. The samples will be characterized as their physicochemical, physicomechanical, porosity and CUR release. In vitro tests will be performed with pre-osteoblastic mouse cells for mineralization, gene expression, cell viability, alkaline phosphatase activity, MTT assay and scanning electron microscopy. (AU)

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(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ALVES, THAIS F. R.; RIOS, ALESSSANDRA C.; PONTES, KATIUSCA DA SILVA; PORTELLA, DECIO L.; ARANHA, NORBERTO; SEVERINO, PATRICIA; SOUTO, ELIANA B.; GONSALVES, JOYCE K. M.; NUNES, ROGERIA DE SOUZA; CHAUD, V, MARCO. Bilayer Mucoadhesive Buccal Film for Mucosal Ulcers Treatment: Development, Characterization, and Single Study Case. PHARMACEUTICS, v. 12, n. 7 JUL 2020. Web of Science Citations: 0.

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