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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Impact of the Content of Fatty Acids of Oral Fat Tolerance Tests on Postprandial Triglyceridemia: Systematic Review and Meta-Analysis

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Monfort-Pires, Milena ; Delgado-Lista, Javier ; Gomez-Delgado, Francisco ; Lopez-Miranda, Jose ; Perez-Martinez, Pablo ; Gouvea Ferreira, Sandra Roberta
Total Authors: 6
Document type: Review article
Source: NUTRIENTS; v. 8, n. 9 SEP 2016.
Web of Science Citations: 9

Whether the content of saturated (SFA), monounsaturated (MUFA), and polyunsaturated fatty acids (PUFA) could differently influence postprandial triglycerides (TG) is unknown. We examined possible differences in the postprandial TG response to fat tolerance tests (FTTs), in which SFA or unsaturated fatty acids were used. Crossover clinical trials investigating the effects of FTTs containing SFA and unsaturated fats on postprandial triglyceridemia in databases from 1994 until 2016 were searched. Of 356 studies, 338 were excluded and 18 were considered. TG net incremental areas under the curve were calculated using time-points or changes from baseline. Pooled effects of standardized mean differences and I-2 test were used. Results: In 12 studies, responses to SFA versus PUFA meals, and in 16 studies versus MUFA meals were compared. Over 4 h, no differences between SFA and unsaturated fats were observed. Over 8 h a lower response to PUFA (SMD -2.28; 95% CI -4.16, -0.41) and a trend to lower response to MUFA (SMD -0.89, 95% CI -1.82, 0.04) were detected. FTTs shorter than 8 h may not be sufficient to differentiate postprandial TG after challenges with distinct fatty acids. Clinical significance of different postprandial TG responses on cardiovascular risk in the long-term deserves investigation. (AU)

FAPESP's process: 12/05503-8 - Does the "mediterranization" of a Brazilian meal induce cardiometabolic benefits?
Grantee:Milena Monfort Pires
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 12/05487-2 - Does the mediterranization of a Brazilian meal induce cardiometabolic benefits?
Grantee:Sandra Roberta Gouvea Ferreira Vivolo
Support type: Regular Research Grants