Detrimental effect of deltamethrin on the central nervous system (synganglion) of Rhipicephalus sanguineus ticks

Author(s)

Pereira, Melissa Carolina ; Gasparotto, Ana Elisa ; Jurgilas, Juliana Paneczko ; Coelho da Silva, Leticia Aurora ; Pereira, Mayara Cristina ; Silveira, Samantha Santos ; Silva, Thays Neigri ; Arnosti, Andre ; Camargo-Mathias, Maria Izabel

• Document type: Journal article
• Source: Experimental and Applied Acarology; v. 71, n. 2, p. 159-169, FEB 2017.
• Web of Science Citations: 3

Abstract

Ticks are ectoparasites of medical and veterinary importance, which transmit many infectious agents, causing significant damage to the hosts. The ``dog tick{''} Rhipicephalus sanguineus is responsible for transmitting several pathogens to dogs, motivating researchers to investigate efficient and sustainable control methods. Currently, chemical acaricides currently in use target the central nervous system (synganglion), which is responsible for controlling all the systemic functions of the ticks. Here, the neurotoxic potential of deltamethrin on the synganglion of unfed R. sanguineus female ticks was investigated. The results showed that the synganglion of the females belonging to the control group presented intact morphological characteristics; however, the ones from the treatment group (exposed to 1.5, 3.12 and 6.25 ppm of deltamethrin) displayed alterations, which were increasingly intense as the concentration increased. Observed alterations were mainly in the cortex region and in the neuropile, indicating that the deltamethrin is neurotoxic. (AU)

• FAPESP's process: 15/20745-6 - Tumor cell line J774 (macrophage) exposure to extract from the salivary glands of Rhipicephalus sanguineus L.S. (Acari: Ixodidae) female ticks: morphophysiological assessment
• Grantee: Melissa Carolina Pereira
• Support Opportunities: Scholarships in Brazil - Scientific Initiation