Advanced search
Start date

Tumor cell line J774 (macrophage) exposure to extract from the salivary glands of Rhipicephalus sanguineus L.S. (Acari: Ixodidae) female ticks: morphophysiological assessment

Grant number: 15/20745-6
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): December 01, 2015
Effective date (End): August 31, 2018
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Pathology
Principal Investigator:Maria Izabel Souza Camargo
Grantee:Melissa Carolina Pereira
Host Institution: Instituto de Biociências (IB). Universidade Estadual Paulista (UNESP). Campus de Rio Claro. Rio Claro , SP, Brazil


Ticks are arthropods and bloodsucking ectoparasites (mandatory) of great economic and medical veterinary importance because they cause damage to hosts and they are one of the major vectors of pathogens, affecting different groups of animals, including man. The Rhipicephalus sanguineus L.S. species, popularly known as "brown dog tick", is geographically distributed around the globe and their biological success is due to the efficient and complex mouthparts that associated with salivary glands act in the production of primary substances in their fixing and feeding processes in the host. Saliva, substance produced and released by the salivary glands, are able to modulate hemostatic, inflammatory and immune responses of the host, and recent studies have also shown antitumor action of saliva components of this tick species which corroborates the importance of studying their effects. In addition, little is known about the physiological and morphological mechanisms that may be involved in the host inflammatory response when it is exposed to glandular extract, so the results that will be obtained in this study from the analysis of these effects may contribute for the development of new forms of control of these ectoparasites. In view of this, this embodiment proposes to study the in vitro effects of the extract of the salivary glands obtained from R. sanguineus female ticks with 2 days feeding, on the tumor cell line J774 (cells derived from macrophages), evaluating what and how occur the possible morphological and physiological changes of these cells due to exposure to the extract. (AU)

News published in Agência FAPESP Newsletter about the scholarship:
Articles published in other media outlets (0 total):
More itemsLess items

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PEREIRA, MELISSA CAROLINA; GASPAROTTO, ANA ELISA; JURGILAS, JULIANA PANECZKO; COELHO DA SILVA, LETICIA AURORA; PEREIRA, MAYARA CRISTINA; SILVEIRA, SAMANTHA SANTOS; SILVA, THAYS NEIGRI; ARNOSTI, ANDRE; CAMARGO-MATHIAS, MARIA IZABEL. Detrimental effect of deltamethrin on the central nervous system (synganglion) of Rhipicephalus sanguineus ticks. Experimental and Applied Acarology, v. 71, n. 2, p. 159-169, . (15/20745-6)
DE ABREU, MARINA RODRIGUES; PEREIRA, MELISSA CAROLINA; SIMIONI, PATRICIA UCELLI; NODARI, ELEN FERNANDA; PAIATTO, LISIERY NEGRINI; CAMARGO-MATHIAS, MARIA IZABEL. Immunomodulatory and morphophysiological effects of Rhipicephalus sanguineus s. l. (Acari: Ixodidae) salivary gland extracts. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, v. 207, p. 36-45, . (18/02999-9, 14/02843-8, 15/20745-6, 13/20258-2)
PEREIRA, MELISSA CAROLINA; NODARI, ELEN FERNANDA; DE ABREU, MARINA RODRIGUES; PAIATTO, LISIERY NEGRINI; SIMIONI, PATRICIA UCELLI; CAMARGO-MATHIAS, MARIA IZABEL. Rhipicephalus sanguineus salivary gland extract as a source of immunomodulatory molecules. Experimental and Applied Acarology, v. 83, n. 3, . (19/02831-3, 18/02999-9, 15/20745-6, 14/02843-8)

Please report errors in scientific publications list using this form.