| Full text | |
| Author(s): |
Vieira, Patricia de Brum
;
Feijo Silva, Nicolas Luiz
;
Silva, Denise Brentan
;
Lopes, Norberto Peporine
;
da Silva, Alexandre Gomes
;
da Silva, Marcia Vanusa
;
Bastida, Jaume
;
Macedo, Alexandre Jose
;
Tasca, Tiana
Total Authors: 9
|
| Document type: | Journal article |
| Source: | Experimental Parasitology; v. 173, p. 18-28, FEB 2017. |
| Web of Science Citations: | 1 |
| Abstract | |
Tritrichomonas foetus infects the bovine urogenital tract, causing bovine trichomoniasis. Significant economic losses may occur due to infertility and abortion among cattle. Trichomonas vaginalis is the causative agent of trichomoniasis; the most common but overlooked non-viral sexually transmitted disease worldwide. Human and bovine trichomoniasis present treatment restrictions and efforts to identify new alternatives are essential. The present study evaluated the anti-trichomonads activities of seven fractions from northwest endemic plant Manilkara rufula. Flavonoids and condensed tannins were identified from these fractions by LC-DAD-MS/MS and MALDI-MS/MS. Altogether, the results demonstrated for the first time the structural description of tannins from leaves of M. rufula and the relation of these compounds with anti-T. vaginalis and anti-T. foetus activities. Overall, this report reveals the potential of M. rufula fractions against both parasites and shows new alternatives to treat the infection caused by trichomonads. (C) 2016 Elsevier Inc. All rights reserved. (AU) | |
| FAPESP's process: | 12/18031-7 - Application of MALDI-MS/MS in the vicenin-2 and derivatives analyses: Understanding the ionization processes to production of the images |
| Grantee: | Denise Brentan da Silva |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 09/54098-6 - Acquisition of a mass spectrometer for the generation of images at the Mass Spectrometry Center of the University of São Paulo Ribeirão Preto School of Pharmaceutical Sciences: studies of molecular localization of biologically active substances |
| Grantee: | Norberto Peporine Lopes |
| Support Opportunities: | Multi-user Equipment Program |