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Studies of adhesion, proliferation and cell death in the interaction of cells with nanostructured materials


The use of nanotechnology in the field of biomaterials is mainly related to the fact the current Materials Science, considered fundamental, yet not be able to build synthetic materials that mimic the nano-characteristics of tissues, factors considered essential for accelerating the adhession process, migration and cell proliferation. Because of the importance of these issues, there is interest in developing three-dimensional porous nanomaterials that mimic in terms of structure, chemical composition and mechanical properties, a natural component of the extracellular matrix present in all tissues of the human body. Carbon nanotubes multiple walls appear as promising for tissue regeneration, because having diameters around 10 to 100 nm, very similar to the physical and structural dimensions of the proteins present in the ECM. The diamond-like carbon is a metastable form of amorphous carbon that combines very attractive physical and chemical properties, such as high mechanical hardness, chemical stability, transparency in the visible, low friction and high wear resistance. These properties make them candidates for use as metal coatings on biomaterials. To be considered the application of nanobiomaterials is necessary to carry out tests in vitro and in vivo in order to understand their properties and utilities. With this, a more detailed study of biocompatibility is necessary, evaluating their possible effects in cell cultures and other organisms, in order that subsequently can be applied as nanobiomaterials in living organisms. The surface properties of a substrate can define the adhesion or not of different organisms and the mechanisms involved. The study of the interaction of protozoan Tritrichomonas foetus and its host is a complex process in which components are involved associated with the surface of the parasite and epithelial host cells. The growth of bacteria is described as a sequence of several steps, and the first represents the adhesion to the surface of the biomaterial. Since bacterial adhesion to surfaces is a prerequisite for infections related to medical devices, there is increasing interest in the development of anti-bacterial surfaces. According to the presented study the compatibility of nanostructured materials with biological structures is needed for biomedical applications. With these data we intend to clarify the biological parameters of nanostructured materials for applications in different fields of biomedicine and engineering. (AU)

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Scientific publications (8)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GUEDES DE OLIVEIRA MORAES, CARLOS DAILTON; GODOI, BRUNO HENRIQUE; SILVA CARVALHO, ISABEL CHAVES; PINTO, JESSICA CRISTINA; ROSSATO, RAFAELLA CARVAIHO; DA SILVA, NEWTON SOARES; SOARES, CRISTINA PACHECO. Genotoxic effects of photodynamic therapy in laryngeal cancer cells - An in vitro study. Experimental Biology and Medicine, v. 244, n. 3, p. 262-271, . (13/20054-8)
RODRIGUES, BRUNO V. M.; LEITE, NELLY C. S.; CAVALCANTI, BRUNO DAS NEVES; DA SILVA, NEWTON S.; MARCIANO, FERNANDA R.; CORAT, EVALDO J.; WEBSTER, THOMAS J.; LOBO, ANDERSON O.. Graphene oxide/multi-walled carbon nanotubes as nanofeatured scaffolds for the assisted deposition of nanohydroxyapatite: characterization and biological evaluation. INTERNATIONAL JOURNAL OF NANOMEDICINE, v. 11, p. 2569-2585, . (11/20345-7, 15/08523-8, 13/20054-8, 11/17877-7)
WACHESK, C. C.; TRAVA-AIROLDI, V. J.; DA-SILVA, N. S.; LOBO, A. O.; MARCIANO, F. R.. The Influence of Titanium Dioxide on Diamond-Like Carbon Biocompatibility for Dental Applications. Journal of Nanomaterials, . (11/20345-7, 13/20054-8, 12/15857-1, 11/17877-7)
RICCI, R.; LEITE, N. C. S.; DA-SILVA, N. S.; PACHECO-SOARES, C.; CANEVARI, R. A.; MARCIANO, F. R.; WEBSTER, T. J.; LOBO, A. O.. Graphene oxide nanoribbons as nanomaterial for bone regeneration: Effects on cytotoxicity, gene expression and bactericidal effect. Materials Science & Engineering C-Materials for Biological Applications, v. 78, p. 341-348, . (11/17877-7, 11/20345-7, 13/14464-9, 13/20054-8, 15/09697-0, 09/18440-1, 16/00575-1)
ZANIN, HUDSON; MANZOLLI RODRIGUES, BRUNO VINICIUS; RIBEIRO NETO, WILSON ALVES; SUMAN BRETAS, ROSARIO ELIDA; DA-SILVA, NEWTON SOARES; MARCIANO, FERNANDA ROBERTA; LOBO, ANDERSON OLIVEIRA. High loading of graphene oxide/multi-walled carbon nanotubes into PDLLA: A route towards the design of osteoconductive, bactericidal and non-immunogenic 3D porous scaffolds. Materials Chemistry and Physics, v. 177, p. 56-66, . (11/17877-7, 11/20345-7, 15/01259-3, 13/20054-8, 14/02163-7, 15/08523-8)
MENEGATTI DE OLIVEIRA, SIMONE MARIA; DA SILVA, NEWTON SOARES; SENE, ANA; GANDRA, RINALDO FERREIRA; BOFF JUNGES, DANIELE SCHAAB; RAMIREZ RAMOS, MARCO ANTONIO; VIEIRA, LUCIA. Comparative Study of Candida albicans Inactivation by Nonthermal Plasma on Stainless Steel with and without Diamond-like Carbon Film. ACS OMEGA, v. 4, n. 4, p. 6891-6902, . (13/20054-8, 17/10491-2)
MARGRAF-FERREIRA, A.; CARVALHO, I. C. S.; MACHADO, S. M.; PACHECO-SOARES, C.; GALVAO, C. W.; ETTO, R. M.; DA SILVA, N. S.. DNA analysis of cattle parasitic protozoan Tritrichomonas foetus after photodynamic therapy. Photodiagnosis and Photodynamic Therapy, v. 18, p. 193-197, . (13/20054-8)
OLIVEIRA, S. M. M.; BARZOTTO, I. L. M.; VIEIRA, L.; SENE, A.; RADI, P. A.; FRAGA, S.; BESSA, M. J.; TEIXEIRA, J. P.; CARVALHO, I. C. S.; DA SILVA, N. S.. Tribocorrosion studies on diamond-like carbon film deposited by PECVD on 304 stainless steel in simulated body fluid. BIOMEDICAL PHYSICS & ENGINEERING EXPRESS, v. 5, n. 4, . (13/20054-8, 17/10491-2)

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