| Grant number: | 13/20054-8 |
| Support Opportunities: | Regular Research Grants |
| Start date: | March 01, 2015 |
| End date: | February 28, 2018 |
| Field of knowledge: | Biological Sciences - Morphology - Cytology and Cell Biology |
| Principal Investigator: | Newton Soares da Silva |
| Grantee: | Newton Soares da Silva |
| Host Institution: | Instituto de Pesquisa e Desenvolvimento (IP&D). Universidade do Vale do Paraíba (UNIVAP). São José dos Campos , SP, Brazil |
| Associated researchers: | Anderson de Oliveira Lobo ; Cristina Pacheco Soares ; Fernanda Roberta Marciano |
Abstract
The use of nanotechnology in the field of biomaterials is mainly related to the fact the current Materials Science, considered fundamental, yet not be able to build synthetic materials that mimic the nano-characteristics of tissues, factors considered essential for accelerating the adhession process, migration and cell proliferation. Because of the importance of these issues, there is interest in developing three-dimensional porous nanomaterials that mimic in terms of structure, chemical composition and mechanical properties, a natural component of the extracellular matrix present in all tissues of the human body. Carbon nanotubes multiple walls appear as promising for tissue regeneration, because having diameters around 10 to 100 nm, very similar to the physical and structural dimensions of the proteins present in the ECM. The diamond-like carbon is a metastable form of amorphous carbon that combines very attractive physical and chemical properties, such as high mechanical hardness, chemical stability, transparency in the visible, low friction and high wear resistance. These properties make them candidates for use as metal coatings on biomaterials. To be considered the application of nanobiomaterials is necessary to carry out tests in vitro and in vivo in order to understand their properties and utilities. With this, a more detailed study of biocompatibility is necessary, evaluating their possible effects in cell cultures and other organisms, in order that subsequently can be applied as nanobiomaterials in living organisms. The surface properties of a substrate can define the adhesion or not of different organisms and the mechanisms involved. The study of the interaction of protozoan Tritrichomonas foetus and its host is a complex process in which components are involved associated with the surface of the parasite and epithelial host cells. The growth of bacteria is described as a sequence of several steps, and the first represents the adhesion to the surface of the biomaterial. Since bacterial adhesion to surfaces is a prerequisite for infections related to medical devices, there is increasing interest in the development of anti-bacterial surfaces. According to the presented study the compatibility of nanostructured materials with biological structures is needed for biomedical applications. With these data we intend to clarify the biological parameters of nanostructured materials for applications in different fields of biomedicine and engineering. (AU)
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