VEGF gene polymorphisms and outcome of epithelial ovarian cancer patients

Camerin, Gabriela Ribeiro; Carvalho Brito, Angelo Borsarelli; Vassallo, Jose; Mauricette Derchain, Sophie Francoise; Passos Lima, Carmen Silvia

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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

VEGF gene polymorphisms and outcome of epithelial ovarian cancer patients

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Author(s):	Camerin, Gabriela Ribeiro ; Carvalho Brito, Angelo Borsarelli ; Vassallo, Jose ; Mauricette Derchain, Sophie Francoise ; Passos Lima, Carmen Silvia Total Authors: 5
Document type:	Journal article
Source:	FUTURE ONCOLOGY; v. 13, n. 5, p. 409-414, FEB 2017.
Web of Science Citations:	6
Abstract
Aim: Since VEGF polymorphisms were associated with variable protein production, we analyzed herein their roles in outcome of epithelial ovarian cancer (EOC) patients. Methods: Genotypes of 85 patients with primary EOC were identified in DNA by real-time PCR. Progression-free survival and overall survival were analyzed using Kaplan-Meier method, univariate Cox model and bootstrap resampling study. Results: At 60 months of follow-up, progression-free survival was shorter in patients with VEGF c.-2578 CC genotype compared with others (52.7 vs 82.2%; p = 0.04). Those patients had 2.15 more chance of presenting disease progression than others (p = 0.04); bootstrap study validated the result (p = 0.03). Conclusion: Our data suggest that VEGF c.-2578C>A polymorphism acts as a prognostic factor in EOC. (AU)

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