| Full text | |
| Author(s): |
Domingues Nazario, Carlos Eduardo
;
Fumes, Bruno Henrique
;
da Silva, Meire Ribeiro
;
Lancas, Fernando Mauro
Total Authors: 4
|
| Document type: | Review article |
| Source: | JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES; v. 1043, p. 81-95, FEB 1 2017. |
| Web of Science Citations: | 19 |
| Abstract | |
The analysis of biological samples is a complex and difficult task owing to two basic and complementary issues: the high complexity of most biological matrices and the need to determine minute quantities of active substances and contaminants in such complex sample. To succeed in this endeavor samples are usually subject to three steps of a comprehensive analytical methodological approach: sample preparation, analytes isolation (usually utilizing a chromatographic technique) and qualitative/quantitative analysis (usually with the aid of mass spectrometric tools). Owing to the complex nature of bio-samples, and the very low concentration of the target analytes to be determined, selective sample preparation techniques is mandatory in order to overcome the difficulties imposed by these two constraints. During the last decade new chemical synthesis approaches has been developed and optimized, such as sol-gel and molecularly imprinting technologies, allowing the preparation of novel materials for sample preparation including graphene and derivatives, magnetic materials, ionic liquids, molecularly imprinted polymers, and much more. In this contribution we will review these novel techniques and materials, as well as their application to the bioanalysis niche. (C) 2016 Elsevier B.V. All rights reserved. (AU) | |
| FAPESP's process: | 12/22055-9 - Development of silica modified with ionic liquids and their use in sample preparation techniques |
| Grantee: | Meire Ribeiro da Silva |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 15/15462-5 - Employment of graphene as sorbent in miniaturized sample preparation techniques. |
| Grantee: | Bruno Henrique Fumes |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 14/07347-9 - Development of novel materials and devices for miniaturized sample preparation techniques in the area of food safety |
| Grantee: | Fernando Mauro Lanças |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 15/12306-2 - Preparation, evaluation and separation optimization of porous-layer open-tubular (PLOT)columns for nano-LC-MS/MS analysis of sulfonamides and their acetylated metabolites in food samples |
| Grantee: | Meire Ribeiro da Silva |
| Support Opportunities: | Scholarships abroad - Research Internship - Doctorate |