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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Noncoding RNA Profiles in Tobacco- and Alcohol-Associated Diseases

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do Amaral, Nayra Soares ; Cruz e Melo, Natalia ; Maia, Beatriz de Melo ; Rocha, Rafael Malagoli
Total Authors: 4
Document type: Review article
Source: GENES; v. 8, n. 1 JAN 2017.
Web of Science Citations: 4

Tobacco and alcohol are the leading environmental risk factors in the development of human diseases, such as cancer, cardiovascular disease, and liver injury. Despite the copious amount of research on this topic, by 2030, 8.3 million deaths are projected to occur worldwide due to tobacco use. The expression of noncoding RNAs, primarily microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), is modulated by tobacco and alcohol consumption. Drinking alcohol and smoking cigarettes can modulate the expression of miRNAs and lncRNAs through various signaling pathways, such as apoptosis, angiogenesis, and inflammatory pathways-primarily interleukin 6 (IL-6)/signal transducer and activator of transcription 3 (STAT3), which seems to play a major role in the development of diseases associated with these risk factors. Since they may be predictive and prognostic biomarkers, they can be used both as predictors of the response to therapy and as a targeted therapy. Further, circulating miRNAs might be valuable noninvasive tools that can be used to examine diseases that are related to the use of tobacco and alcohol. This review discusses the function of noncoding RNAs in cancer and other human tobacco- and alcohol-associated diseases. (AU)

FAPESP's process: 14/03021-1 - Identification of microRNAs differentially expressed in serous carcinomas of high-grade patients with different clinical outcomes
Grantee:Nayra Soares Do Amaral
Support type: Scholarships in Brazil - Doctorate