Comparison of estimates of body fat content in childhood-onset systemic lupus erythematosus

Author(s)

Sinicato, N. A. ; Peres, F. A. ; de Oliveira Pelicari, K. ; de Oliveira Santos, A. ; Ramos, C. D. ; Marini, R. ; Appenzeller, S.

• Document type: Journal article
• Source: Lupus; v. 26, n. 4, p. 417-425, APR 2017.
• Web of Science Citations: 1

Abstract

Objective We aimed to compare estimates of body fat content with respect to their ability to predict the percentage of body fat, confirmed by dual-energy X-ray absorptiometry scans in childhood-onset systemic lupus erythematosus. Methods We included 64 consecutive childhood-onset systemic lupus erythematosus patients and 64 healthy age and sex-matched controls in a cross-sectional study. Anthropometric data, body mass index and body adiposity index were calculated for all subjects. Childhood-onset systemic lupus erythematosus patients were further assessed for clinical and laboratory childhood-onset systemic lupus erythematosus manifestations and fat mass, lean mass and percentage of body fat evaluated by dual-energy X-ray absorptiometry. Results Elevated waist/hip ratio was observed in childhood-onset systemic lupus erythematosus patients when compared to controls (p<0.001). We did not find differences between body mass index and body adiposity index classification in childhood-onset systemic lupus erythematosus patients and controls. Using dual-energy X-ray absorptiometry as gold standard we observed that all indirect estimates of body fat were correlated with whole body fat mass. We observed a correlation between height and cumulative corticosteroid dose adjusted by weight (r=0.429, p=0.005) in childhood-onset systemic lupus erythematosus. On whole body analysis we observed a correlation between lean mass and ACR Damage Index scores (r=-0.395; p=0.019); percentage of body fat and adjusted Systemic Lupus Erythematosus Disease Activity Index (r=0.402; p=0.008), disease duration (r=-0.370; p=0.012). On trunk analysis we observed a correlation between lean mass and ACR Damage Index (r=-0.319; p=0.042); percentage of body fat with adjusted Systemic Lupus Erythematosus Disease Activity Index (r=0.402; p=0.005), disease duration (r=-0.408; p=0.005). Conclusions This is the first study analyzing body adiposity index in childhood-onset systemic lupus erythematosus patients. We observed that all indirect estimates of body fat were correlated with whole body fat mass. This study shows that we should not replace body mass index by body adiposity index to evaluating fat levels in childhood-onset systemic lupus erythematosus. In consideration of the importance of overweight classification in cardiovascular diseases, any direct estimates of body fat can be used in an attempt to improve the prognosis of patients. Note We believe that we have presented evidence of body adiposity index accuracy in childhood-onset systemic lupus erythematosus patients but further research on the generalizability of body adiposity index to other patient groups needs to be done. (AU)

• FAPESP's process: 09/06049-6 - Blood and cerebrospinal fluid biomarkers associated with structural and functional central nervous system abnormalities in Systemic lupus erythematosus
• Grantee: Simone Appenzeller
• Support Opportunities: Scholarships in Brazil - Young Researchers
• FAPESP's process: 09/15286-1 - PREVALENCE AND FACTORS ASSOCIATED WITH THE METABOLIC SYNDROME IN YOUNG SYSTEMIC LUPUS ERYTEMATOSUS
• Grantee: Nailú Angélica Sinicato Martin
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 08/02917-0 - Blood and cerebrospinal fluid biomarkers associated with structural and functional central nervous system abnormalities in systemic lupus erythematosus
• Grantee: Simone Appenzeller
• Support Opportunities: Research Grants - Young Investigators Grants