Bone Healing Evaluation in Critical-Size Defects Treated With Xenogenous Bone Plus Porcine Collagen

Author(s)

Maciel, Juceleia ; Correa Momesso, Gustavo Antonio ; Ramalho-Ferreira, Gabriel ; Consolaro, Renata Bianco ; Perri de Carvalho, Paulo Sergio ; Faverani, Leonardo Perez ; Farnezi Bassi, Ana Paula

• Document type: Journal article
• Source: IMPLANT DENTISTRY; v. 26, n. 2, p. 296-302, APR 2017.
• Web of Science Citations: 3

Abstract

Purpose:This study aimed to evaluate the osteoconductive features of Bio-Oss Collagen in large critical-size defects (8 mm).Materials and Methods:Thirty-six adult Wistar Albinus male adult rats were carried out a critical-size defect with a trephine bur of 8 mm in the calvaria. Groups were divided depending on the filling biomaterial as follows: group BO: Bio-Oss (n = 18); group BOC: Bio-Oss Collagen (n = 18). After 7, 30, and 60 days, 6 rats of each group were euthanized with anesthetic overdose. Specimens were laboratory processed for histomorphometric analysis. Histomorphometric data were statistically analyzed by analysis of variance and post-Tukey test (P < 0.05).Results:Statistical differences were found in new bone formation just in the intragroup comparison among periods after 7 and 60 postoperative days, indicating more new bone formation after 60 days (Tukey test, P = 0.029).Conclusion:Under the limitation of this research, it could be concluded that Bio-Oss and Bio-Oss Collagen in this experimental model did not show osteoconductive features. (AU)

• FAPESP's process: 13/18339-4 - Bone repair evaluation of critical rats calvarial deffects filled with Bio-Oss or Bio-Oss collagen
• Grantee: Ana Paula Farnezi Bassi
• Support Opportunities: Regular Research Grants
• FAPESP's process: 13/06805-0 - Bone repair evaluation of critical rats calvarial defects filled with Bio-Oss or Bio-Oss Collagen
• Grantee: Francisco Marques de Melo Netto
• Support Opportunities: Scholarships in Brazil - Scientific Initiation