| Full text | |
| Author(s): |
Stocco, T. D.
;
Rodrigues, B. V. M.
;
Marciano, F. R.
;
Lobo, A. O.
Total Authors: 4
|
| Document type: | Journal article |
| Source: | Materials Letters; v. 196, p. 221-224, JUN 1 2017. |
| Web of Science Citations: | 15 |
| Abstract | |
The tissue engineering field has provided great efforts towards the development of potential treatments for meniscal injuries. The success of these strategies are linked to the creation of scaffolds that are able to mimic the extracellular matrix architecture of the native meniscus. However, most conventional electrospinning setups can only produce either 2D aligned fibrous structures or 3D fibrous scaffolds with fibers randomly distributed. Herein, we designed a novel electrospinning setup, which consisted of two metallic devices as collectors: an external cylindrical hollow piece with a central pin and a mobile internal hollow cylinder. A feasible approach to create single-layer scaffolds with both circumferentially and radially aligned ultrathin fibers was developed. Then, this investigation demonstrated a great potential for the application of these scaffolds towards meniscus tissue engineering, once they are able to reproduce the orientation of the main collagen fibers present in the extracellular matrix of the knee meniscus. (C) 2017 Elsevier B.V. All rights reserved. (AU) | |
| FAPESP's process: | 11/17877-7 - Development of new polymeric scaffolds by electrospinning technique with incorporation of vertically aligned carbon nanotubes and nanohidroxyapatite for bone tissue regeneration |
| Grantee: | Anderson de Oliveira Lobo |
| Support type: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 15/08523-8 - Development of a fluorescent nanosensor from the electrospinning of PVA and graphene quantum dots: application in the detection of Alzheimer's biomarkers |
| Grantee: | Bruno Vinícius Manzolli Rodrigues |
| Support type: | Scholarships in Brazil - Post-Doctorate |
| FAPESP's process: | 11/20345-7 - Study of nanoparticle-incorporated diamond-like carbon films for biomedical applications |
| Grantee: | Fernanda Roberta Marciano |
| Support type: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 16/00575-1 - Functional biomembranes based on peptides and bottlebrush polymers to tissue engineering |
| Grantee: | Fernanda Roberta Marciano |
| Support type: | Scholarships abroad - Research |
| FAPESP's process: | 15/09697-0 - Electrospinning of novel functional nanobiomaterials based on peptides and bottlebrush polymers for tissue engineering |
| Grantee: | Anderson de Oliveira Lobo |
| Support type: | Scholarships abroad - Research |