Increased expression of tissue inhibitor of metalloproteinase-1 correlates with improved outcome in canine cutaneous mast cell tumours

Author(s)

Pulz, L. H. ; Barra, C. N. ; Kleeb, S. R. ; Xavier, J. G. ; Catao-Dias, J. L. ; Sobral, R. A. ; Fukumasu, H. ; Strefezzi, R. F.

• Document type: Journal article
• Source: VETERINARY AND COMPARATIVE ONCOLOGY; v. 15, n. 2, p. 606-614, JUN 2017.
• Web of Science Citations: 7

Abstract

Canine mast cell tumour (MCT) is a biologically heterogeneous disease. The extracellular matrix degradation promoted by matrix metalloproteinases (MMPs) has been studied in an attempt to elucidate the mechanisms involved in the biological behaviour of tumours. The aim of this study was to characterize the expression of MMP-2 and -9 and tissue inhibitors of metalloproteinase (TIMP)-1 and -2 in canine cutaneous MCTs and to evaluate their prognostic values. Immunohistochemical staining for MMP-2, MMP-9, TIMP-2 and TIMP-1 was performed in 46 canine cases of MCTs. TIMP-1 expression showed an independent prognostic value for post-surgical survival and disease-related mortality. Dogs with MCTs showing less than 22.9% mast cell TIMP-1 positivity were more prone to die because of the disease and had a shorter post-surgical survival. This article suggests the involvement of TIMP-1 in MCT progression, by contributing to a good outcome in patients with MCTs. (AU)

• FAPESP's process: 10/05094-5 - Evaluation of VEGF, VEGFR and matrix metalloproteinase-9 immunohistochemical expressions as potential prognostic indicators for canine cutaneous mast cell tumors
• Grantee: Ricardo de Francisco Strefezzi
• Support Opportunities: Regular Research Grants
• FAPESP's process: 13/13252-8 - Characterization of apoptosis related genes in canine cutaneous mast cell tumors and its value as prognostic indicators
• Grantee: Ricardo de Francisco Strefezzi
• Support Opportunities: Regular Research Grants