| Full text | |
| Author(s): |
Santana Gondim, Antonio Nei
;
Lara, Aline
;
Santos-Miranda, Artur
;
Roman-Campos, Danilo
;
Lauton-Santos, Sandra
;
Rodrigues Menezes-Filho, Jose Evaldo
;
Lins de Vasconcelos, Carla Maria
;
Conde-Garcia, Eduardo Antonio
;
Guatimosim, Silvia
;
Cruz, Jader S.
Total Authors: 10
|
| Document type: | Journal article |
| Source: | European Journal of Pharmacology; v. 807, p. 56-63, JUL 15 2017. |
| Web of Science Citations: | 4 |
| Abstract | |
(-)-Terpinen-4-ol is a naturally occurring plant monoterpene and has been shown to have a plethora of biological activities. The objective of this study was to investigate the effects of (-)-terpinen-4-ol on the rat heart, a key player in the control and maintenance of arterial blood pressure. The effects of (-)-terpinen-4-ol on the rat heart were investigated using isolated left atrium isometric force measurements, in vivo electrocardiogram (ECG) recordings, patch clamp technique, and confocal microscopy. It was observed that (-)-terpinen-4-ol reduced contraction force in an isolated left atrium at millimolar concentrations. Conversely, it induced a positive inotropic effect and extrasystoles at micromolar concentrations, suggesting that (-)-terpinen-4-ol may have arrhythmogenic activity on cardiac tissue. In anaesthetized animals, (-)-terpinen-4-ol also elicited rhythm disturbance, such as supraventricular tachycardia and atrioventricular block. To investigate the cellular mechanism underlying the dual effect of (-)-terpinen-4-ol on heart muscle, experiments were performed on isolated ventricular cardiomyocytes to determine the effect of (-)-terpinen-4-ol on L-type Ca2+ currents, Ca2+ sparks, and Ca2+ transients. The arrhythmogenic activity of (-)-terpinen-4-ol in vitro and in vivo may be explained by its effect on intracellular Ca2+ handling. Taken together, our data suggest that (-)-terpinen-4-ol has cardiac arrhythmogenic activity. (AU) | |
| FAPESP's process: | 14/09861-1 - The role of late sodium current in the inherited and acquired cardiac arrhythmias: from the biophysics properties to new therapeutic targets |
| Grantee: | Danilo Roman Campos |
| Support Opportunities: | Research Grants - Young Investigators Grants |