One-step syntheses of substituted 2-pyrrolidinones and 3-pyrrolidinones from alpha,beta-unsaturated diazoketones and amines. Application in the synthesis of barmumycin

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Author(s):	Dias, Rafael M. P. ; Momo, Patricia B. ; Burtoloso, Antonio C. B. Total Authors: 3
Document type:	Journal article
Source:	Tetrahedron; v. 73, n. 26, p. 3720-3729, JUN 29 2017.
Web of Science Citations:	7
Abstract
A simple and one-pot way to prepare substituted 2-and 3-pyrrolidinones is described. The method uses unsaturated diazoketones (obtained from aldeydes in a single step) and amines, and provide an easy access to these important classes of nitrogen heterocycles. Furthermore, application of this methodology to the synthesis of the natural product barmumycin is achieved in 3 steps from these diazoketones. (C) 2017 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process:	13/18009-4 - Molecular design, synthesis and trypanocidal activity of cruzain reversible covalent inhibitors
Grantee:	Carlos Alberto Montanari
Support Opportunities:	Research Projects - Thematic Grants


FAPESP's process:	13/25504-1 - Development of new methodologies for the asymmetric a-functionalization of carbonyl compounds using chiral catalysts
Grantee:	Antonio Carlos Bender Burtoloso
Support Opportunities:	Regular Research Grants


FAPESP's process:	15/22003-7 - Asymmetric Aza-Michael Addition from unsaturated diazoketones.
Grantee:	Patrícia Betoni Momo
Support Opportunities:	Scholarships in Brazil - Post-Doctoral