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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

One-step syntheses of substituted 2-pyrrolidinones and 3-pyrrolidinones from alpha,beta-unsaturated diazoketones and amines. Application in the synthesis of barmumycin

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Author(s):
Dias, Rafael M. P. ; Momo, Patricia B. ; Burtoloso, Antonio C. B.
Total Authors: 3
Document type: Journal article
Source: Tetrahedron; v. 73, n. 26, p. 3720-3729, JUN 29 2017.
Web of Science Citations: 7
Abstract

A simple and one-pot way to prepare substituted 2-and 3-pyrrolidinones is described. The method uses unsaturated diazoketones (obtained from aldeydes in a single step) and amines, and provide an easy access to these important classes of nitrogen heterocycles. Furthermore, application of this methodology to the synthesis of the natural product barmumycin is achieved in 3 steps from these diazoketones. (C) 2017 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 13/18009-4 - Molecular design, synthesis and trypanocidal activity of cruzain reversible covalent inhibitors
Grantee:Carlos Alberto Montanari
Support type: Research Projects - Thematic Grants
FAPESP's process: 13/25504-1 - Development of new methodologies for the asymmetric a-functionalization of carbonyl compounds using chiral catalysts
Grantee:Antonio Carlos Bender Burtoloso
Support type: Regular Research Grants
FAPESP's process: 15/22003-7 - Asymmetric Aza-Michael addition from unsaturated diazoketones
Grantee:Patrícia Betoni Momo
Support type: Scholarships in Brazil - Post-Doctorate