Quantitative Myasthenia Gravis Score: a Brazilian multicenter study for translation, cultural adaptation and validation

Author(s):Show less -

Oliveira, Ezequiel Fernandes ; Oliveira Valerio, Berenice Cataldo ; Cavalcante, Valeria ; Urbano, Jessica Julioti ; Silva, Anderson Soares ; Polaro, Melissa Nunes ; Nacif, Sergio Roberto ; Oliveira, Claudia Santos ; Dutra Resendes, Maria Bemadete ; Butte Oliveira, Acary Souza ; Franco Oliveira, Luis Vicente

• Document type: Journal article
• Source: Arquivos de Neuro-Psiquiatria; v. 75, n. 7, p. 457-463, JUL 2017.
• Web of Science Citations: 1

Abstract

ABSTRACT Objective To perform the translation, cross-cultural adaptation and validation of the Quantitative Myasthenia Gravis Score (QMGS) to Brazilian Portuguese in accordance with international ethical standards. Methods The following steps were taken: (1) implementation of the translation protocol and transcultural adaptation, (2) validation of the adapted content, and (3) assessment of reliability. To check intra- and inter-observer reproducibility, each patient underwent two interviews with interviewer-A and one with B. The QMGS was compared to the Myasthenia Gravis Composite Scale and Myasthenia-specific Quality of Life Questionnaire. Results Our study group consisted of 30 patients, with a mean age of 47.6±11.4 years and a mean duration of illness of 11.33±8.49 years. Correlation between the QMGS and MGC was very strong (r = 0.928; p < 0.001) and substantial between the QMGS and MG-QOL 15 (r = 0.737; p < 0.001). Conclusion The Brazilian Portuguese translation, and validation of the QMGS was successfully performed. (AU)

• FAPESP's process: 15/11738-6 - Sleep study, lung function, respiratory muscle strength and validation of two instruments of clinical outcome in patients with myasthenia gravis: Myasthenia gravis Quantitative testing form and MG Composite Scale.
• Grantee: Ezequiel Fernandes de Oliveira
• Support Opportunities: Scholarships in Brazil - Doctorate