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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Chemical Composition, Antibacterial, Schistosomicidal, and Cytotoxic Activities of the Essential Oil of Dysphania ambrosioides (L.) Mosyakin & Clemants (Chenopodiaceae)

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Soares, Marina H. ; Dias, Herbert J. ; Vieira, Tatiana M. ; de Souza, Maria G. M. ; Cruz, Ana F. F. ; Badoco, Fernanda R. ; Nicolella, Heloiza D. ; Cunha, Wilson R. ; Groppo, Milton ; Martins, Carlos H. G. ; Tavares, Denise C. ; Magalhaes, Lizandra G. ; Crotti, Antonio E. M.
Total Authors: 13
Document type: Journal article
Source: CHEMISTRY & BIODIVERSITY; v. 14, n. 8 AUG 2017.
Web of Science Citations: 7
Abstract

We have investigated the chemical composition and the antibacterial activity of the essential oil of Dysphania ambrosioides (L.) Mosyakin \& Clemants (Chenopodiaceae) (DA-EO) against a representative panel of cariogenic bacteria. We have also assessed the invitro schistosomicidal effects of DA-EO on Schistosoma mansoni and its cytotoxicity to GM07492-A cells invitro. Gas chromatography (GC) and gas chromatography-mass spectrometry (GC/MS) revealed that the monoterpenes cis-piperitone oxide (35.2%), p-cymene (14.5%), isoascaridole (14.1%), and -terpinene (11.6%) were identified by as the major constituents of DA-EO. DA-EO displayed weak activity against Streptococcus sobrinus and Enterococcus faecalis (minimum inhibitory concentration (MIC)=1000g/ml). On the other hand, DA-EO at 25and 12.5g/ml presented remarkable schistosomicidal action invitro and killed 100% of adult worm pairs within 24 and 72h, respectively. The LC50 values of DA-EO were 6.50 +/- 0.38, 3.66 +/- 1.06, and 3.65 +/- 0.76g/ml at 24, 48, and 72h, respectively. However, DA-EO at concentrations higher than 312.5g/ml significantly reduced the viability of GM07492-A cells (IC50=207.1 +/- 4.4g/ml). The selectivity index showed that DA-EO was 31.8 times more toxic to the adult S. mansoni worms than GM07492-A cells. Taken together, these results demonstrate the promising schistosomicidal potential of the essential oil of Dysphania ambrosioides. (AU)

FAPESP's process: 16/19272-9 - Evaluation of the antimicrobial activity of curcuminoids and study of their fragmentation reactions in the gas-phase by tandem mass spectrometry
Grantee:Tatiana Manzini Vieira
Support type: Scholarships in Brazil - Master