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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

A strategy for the identification of patterns in the biosynthesis of nonribosomal peptides by Betaproteobacteria species

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Baldim, Joao Luiz ; da Silva, Bruna Lidiane ; Chagas-Paula, Daniela Aparecida ; Lago, Joao Henrique G. ; Soares, Marisi G.
Total Authors: 5
Document type: Journal article
Source: SCIENTIFIC REPORTS; v. 7, SEP 4 2017.
Web of Science Citations: 0

Nonribosomal peptides have an important pharmacological role due to their extensive biological properties. The singularities in the biosynthesis of these natural products allowed the development of genome-mining strategies which associate them to their original biosynthetic gene clusters. Generally, these compounds present complex architectures that make their identification difficult. Based on these evidences, genomes from species of the class Betaproteobacteria were studied with the purpose of finding biosynthetic similarities among them. These organisms were applied as templates due to their large number of biosynthetic gene clusters and the natural products isolated from them. The strategy for Rapid Identification of Nonribosomal Peptides Portions (RINPEP) proposed in this work was built by reorganizing the data obtained from antiSMASH and NCBI with a product-centered way. The verification steps of RINPEP comprehended the fragments of existent compounds and predictions obtained in silico with the purpose of finding common subunits expressed by different genomic sequences. The results of this strategy revealed patterns in a global overview of the biosynthesis of nonribosomal peptides by Betaproteobacteria. (AU)

FAPESP's process: 16/19269-8 - Metabolic induction guided by genomic-mining strategies in Burkholderia thailandensis for the biosynthesis of antibiotic-like natural products
Grantee:Joao Luiz Baldim Zanin
Support type: Scholarships in Brazil - Post-Doctorate