| Full text | |
| Author(s): |
Pulz, L. H.
;
Strefezzi, R. F.
Total Authors: 2
|
| Document type: | Review article |
| Source: | VETERINARY AND COMPARATIVE ONCOLOGY; v. 15, n. 3, p. 669-683, SEP 2017. |
| Web of Science Citations: | 4 |
| Abstract | |
The extracellular matrix (ECM) is composed of several types of proteins, which interact and form dynamic networks. These components can modulate cell behaviour and actively influence the growth and differentiation of tissues. ECM is also important in several pathological processes, such as cancer invasion and metastasis, by creating favourable microenvironments. Proteolysis in neoplastic tissues is mediated by proteinases, whose regulation involves complex interactions between neoplastic cells and non-neoplastic stromal cells. In this review, we discuss aspects of proteinase expression and tumor behaviour in humans and dogs. Different classes of proteases are summarized, with special emphasis being placed on molecules that have been shown to correlate with prognosis, reinforcing the need for a better understanding of the regulation of this microenvironment and its influences in tumor progression and metastasis, which should significantly aid the development of improved prognosis and treatment. (AU) | |
| FAPESP's process: | 10/05094-5 - Evaluation of VEGF, VEGFR and matrix metalloproteinase-9 immunohistochemical expressions as potential prognostic indicators for canine cutaneous mast cell tumors |
| Grantee: | Ricardo de Francisco Strefezzi |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 13/13252-8 - Characterization of apoptosis related genes in canine cutaneous mast cell tumors and its value as prognostic indicators |
| Grantee: | Ricardo de Francisco Strefezzi |
| Support Opportunities: | Regular Research Grants |