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Metal-organic frameworks analogous to MIL-101 for controlled drug delivery

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Irlene Maria Pereira e Silva
Total Authors: 1
Document type: Doctoral Thesis
Press: Campinas, SP.
Institution: Universidade Estadual de Campinas (UNICAMP). Instituto de Química
Defense date:
Examining board members:
André Luiz Barboza Formiga; Wilton Rogério Lustri; Alexandre Cuin; Diego Pereira dos Santos; Camilla Abbehausen
Advisor: André Luiz Barboza Formiga

METAL-ORGANIC FRAMEWORKS ANALOGOUS TO MIL-101 FOR CONTROLLED DRUG DELIVERY. MIL-101 (Cr) and its structural analogues containing 10 and 20% amino groups were used for the incorporation and in vitro release of ibuprofen, nimesulide and levofloxacin. The functionalization with NH2 favored the interactions between the matrix and the functional groups of the drugs, improving the release control. In addition to the functionalization, the surface area and pore volume also affect the amount of incorporation and release. Levofloxacin incorporated into the matrix presented antibacterial activity for Gram-positive (S. aureus) and Gram-negative (P. aeruginosa) bacterial strains, in comparison with free levofloxacin. The stability tests of the matrices investigated in simulated gastric (SGF, pH = 1.2), simulated intestinal (SIF, pH = 7.4) and simulated body (SBF, pH =7.4) fluids showed that the release of chromium(III) ions is most sharp in the first day, wherein the MIL-101 (Cr) and 10%NH2 release smaller amounts of ions. These matrices are more stable than 20%NH2. Furthermore, a Ag(I) complex with ibuprofen was synthesized and showed a good activity against Gram-positive (S. aureus ATCC 25923, S. aureus and S. aureus BEC9393 Rib1) and Gram-negative (E. coli ATCC 25922, P. aeruginosa ATCC 27853 and P. aeruginosa 31NM) bacterial strains. Unfortunately, it could not be used in the incorporation studies due to low solubility (AU)

FAPESP's process: 12/17043-1 - Metal-organic frameworks for controlled drug delivery
Grantee:Irlene Maria Pereira e Silva
Support Opportunities: Scholarships in Brazil - Doctorate