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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The nucleus raphe magnus modulates hypoxia-induced hyperventilation but not anapyrexia in rats

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Author(s):
Gargaglioni, Luciane H. ; Coimbra, Norberto C. [2] ; Branco, Luiz G. S.
Total Authors: 3
Document type: Journal article
Source: Neuroscience Letters; v. 347, n. 2, p. 121-125, Aug. 2004.
Field of knowledge: Biological Sciences - Physiology
Abstract

The nucleus raphe magnus (NRM) is one of the brainstem cell groups involved in physiological responses to hypoxia. Thus, we tested the hypothesis that the NRM modulates hypoxia-induced hyperventilation and anapyrexia. To this end, we assessed the participation of NRM in the respiratory and thermoregulatory responses to hypoxia using ibotenic acid lesions produced in the NRM of rats. Our results demonstrated that, under resting breathing, NRM plays no role in ventilation or body temperature. Hypoxia caused hyperventilation and anapyrexia in all groups. NMR lesions elicited an increased ventilatory response to hypoxia due to a higher tidal volume (VT) but did not affect hypoxia-induced anapyrexia. Therefore, we conclude that NRM exerts an inhibitory modulation of breathing during hypoxia, acting on VT, but plays no role in the hypoxia-induced anapyrexia. (AU)