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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Litter size determines the number of melanin-concentrating hormone neurons in the medial preoptic area of Sprague Dawley lactating dams

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Pacheco Ferreira, Jozelia Gomes [1] ; Gomes Duarte, Jessica Catharine [1] ; Diniz, Giovanne Baroni [1] ; Bittencourt, Jackson Cioni [2, 1]
Total Authors: 4
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Anat, Lab Chem Neuroanat, Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Psychol, Ctr Neurosci & Behav, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Physiology & Behavior; v. 181, p. 75-79, NOV 1 2017.
Web of Science Citations: 2

Melanin-concentrating hormone {[}MCH] is an important neuromodulator related to motivated behaviors. The MCH-containing neurons are mainly located in the lateral hypothalamic area, zona incerta, and incerto-hypothalamic area. In the medial preoptic area {[}MPOA], a key region for the regulation of maternal behavior, Pinch mRNA expression and MCH synthesis can be detected exclusively during the lactation period. As litter size affects different parameters of maternal physiology, the aim of this study was to verify whether litter size can modulate the number of MCH-containing neurons in the MPOA of lactating rats. The dams were divided into the following groups: postpartum day 12, 15, or 19, with a large, small or reduced litter. Our results show that the number of MCH-immunoreactive neurons in the MPOA is positively correlated with the number of pups in the litter and that artificially reducing the number of pups can also decrease the number of MCH-inununoreactive neurons in the MPOA. (AU)

FAPESP's process: 15/05990-4 - The melanin-concentrating hormone [MCH] peptidergic system: neurogenesis and lactation
Grantee:Jozélia Gomes Pacheco Ferreira
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 16/02748-0 - Study of the anatomical basis for a volume transmission mechanism on the Melanin Concentrating Hormone [MCH] peptidergic system
Grantee:Giovanne Baroni Diniz
Support type: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 16/02224-1 - The existence of neurogenesis during the lactation period
Grantee:Jackson Cioni Bittencourt
Support type: Research Projects - Thematic Grants
FAPESP's process: 10/52068-0 - The putative envolvement of melanin-concentrating hormone in the control of lactation
Grantee:Jackson Cioni Bittencourt
Support type: Research Projects - Thematic Grants
FAPESP's process: 16/19845-9 - Characterization of the melanin-concentrating hormone receptor 1 (MCHR1) in the brain, mammary gland, uterus and ovaries in wild type and MCHR1 knockout mice
Grantee:Jozélia Gomes Pacheco Ferreira
Support type: Scholarships abroad - Research Internship - Post-doctor