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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Green Determination of Urea in Moisturizers by Diffuse Reflectance Spectroscopy

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Author(s):
Bueno Toledo, Paulo Roberto A. [1] ; Toci, Aline Theodoro [2] ; Pezza, Helena Redigolo [1] ; Pezza, Leonardo [1]
Total Authors: 4
Affiliation:
[1] Sao Paulo State Univ UNESP, Inst Chem, R Prof Francisco Degni 55, POB 355, BR-14800900 Araraquara, SP - Brazil
[2] Fed Univ Latin Amer Integrat UNILA, Latin Amer Inst Sci Life & Nat, Foz Do Iguacu, Parana - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Analytical Letters; v. 50, n. 12, p. 2030-2043, 2017.
Web of Science Citations: 0
Abstract

This manuscript describes the development and application of a simple, inexpensive, and green method for the quantification of urea in skin moisturizer creams, using a combined spot test/diffuse reflectance spectroscopy procedure. The method is based on the derivatization of urea with a chromogenic reagent (p-dimethylaminocinnamaldehyde) in acidic methanol, yielding a colored compound on the surface of filter paper. The reaction parameters were optimized using chemometric experimental design. Reflectometric measurements of the colored compound were performed at 530nm, the wavelength of maximum absorption. The linear dynamic range was from 25 to 750mgL(-1). The detection and quantification limits were 6.50 and 21.65mgL(-1), respectively. The method was successfully used for the determination of urea in skin moisturizer creams, demonstrating that it is a reliable eco-friendly alternative. (AU)

FAPESP's process: 15/21733-1 - Development of vanguard analytical methods using spot test and paper-based microfluidic device.
Grantee:Helena Redigolo Pezza
Support Opportunities: Regular Research Grants