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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Gut microbiota and antimicrobial peptides

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Author(s):
Sivieri, Katia [1] ; Bassan, Juliana [1] ; Peixoto, Guilherme [2] ; Monti, Rubens [1]
Total Authors: 4
Affiliation:
[1] Univ Estadual Paulista, UNESP, Fac Pharmaceut Sci, Dept Food & Nutr, Rodovia Araraquara Jau Km 1 S-N, BR-14800903 Araraquara, SP - Brazil
[2] Univ Estadual Paulista, UNESP, Fac Pharmaceut Sci, Dept Bioproc & Biotechnol, Rodovia Araraquara Jau Km 1 S-N, BR-14800903 Araraquara, SP - Brazil
Total Affiliations: 2
Document type: Review article
Source: CURRENT OPINION IN FOOD SCIENCE; v. 13, p. 56-62, FEB 2017.
Web of Science Citations: 2
Abstract

This mini-review covers the potential interactions between gut microbiota and antimicrobial peptides, as well as the main mechanisms of action of antimicrobial peptides. One of the most efficient molecules produced by resident gut microbiota are peptides, which have antimicrobial functions and an innate immune response against infectious agents. Currently, more than 2300 AMPs have been isolated. The human gut microbiota regulates the production of defensins, cathelicidins, C-type lectins, ribonucleases, and S100 proteins in intestinal epithelial cells and Paneth cells, which rapidly kill or inactivate invading microorganisms. The study of gut microbiota and new peptides provides perspective for the synthesis of analogous molecules as an alternative in solving the problem of multidrug resistance reported with conventional antibiotics. (AU)

FAPESP's process: 14/12563-2 - Agro industrial residues as solid support for immobilization and stabilization of enzymes of biotechnological interest
Grantee:Rubens Monti
Support Opportunities: Regular Research Grants