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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

METABOLOMICS: DEFINITIONS, STATE-OF-THE-ART AND REPRESENTATIVE APPLICATIONS

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Author(s):
Gisele A. B. Canuto [1] ; José Luiz da Costa [2] ; Pedro L. R. da Cruz [3] ; Ana Rosa L. de Souza [4] ; Andréa T. Faccio [5] ; Aline Klassen [6] ; Karina T. Rodrigues [7] ; Marina F. M. Tavares [8]
Total Authors: 8
Affiliation:
[1] Universidade de São Paulo. Instituto de Química. Departamento de Química Fundamental - Brasil
[2] Universidade Estadual de Campinas. Faculdade de Ciências Farmacêuticas. Centro de Controle de Intoxicações - Brasil
[3] Universidade de São Paulo. Instituto de Química. Departamento de Química Fundamental - Brasil
[4] Universidade de São Paulo. Instituto de Química. Departamento de Química Fundamental - Brasil
[5] Universidade de São Paulo. Instituto de Química. Departamento de Química Fundamental - Brasil
[6] Universidade Federal de São Paulo. Departamento de Química - Brasil
[7] Universidade de São Paulo. Instituto de Química. Departamento de Química Fundamental - Brasil
[8] Universidade de São Paulo. Instituto de Química. Departamento de Química Fundamental - Brasil
Total Affiliations: 8
Document type: Journal article
Source: Química Nova; v. 41, n. 1, p. 75-91, 2018-01-00.
Abstract

Metabolomics is an emerging and promising omics approach used to understand biological mechanisms. By untargeted and targeted metabolomics analyses, metabolites are determined in biological samples (fluids, cells, tissues, etc.) by comparison of control groups with altered groups, undergoing different therapies, submitted to differing stress levels, dietary modulation, or promoted by a disease, or specific condition, etc., using sophisticated analytical techniques, and advanced data treatment and statistical analyses. In this review, the concepts involved in metabolomics studies were presented, describing in details all steps involved in the metabolomics workflow, for untargeted and targeted strategies. Finally, the potential of metabolomics is illustrated by applications in representative areas: clinical, environmental, food and nutrition, forensic toxicology, microbiology, parasitology, plants, and sports. Relevant reviews were compiled to characterize each of these areas, and a corresponding application of untargeted and targeted metabolomics were described. (AU)

FAPESP's process: 12/07361-6 - Mobility modulation in capillary electrophoresis
Grantee:Marina Franco Maggi Tavares
Support Opportunities: Regular Research Grants
FAPESP's process: 12/09822-0 - Evaluation of urinary global fingerprint of vesicoureteral reflux for CE-MS
Grantee:Karina Trevisan Rodrigues
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 15/10650-8 - Stability of medicines, drugs of abuse and pesticides in dried blood spots (DBS), and its application in forensic toxicology
Grantee:José Luiz da Costa
Support Opportunities: Regular Research Grants
FAPESP's process: 12/51692-7 - Role of adaptative immunity on the progress of ischemic heart disease after acute myocardial infarction
Grantee:Francisco Antonio Helfenstein Fonseca
Support Opportunities: Research Projects - Thematic Grants