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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Zika virus infection in a pediatric patient with acute gastrointestinal involvement

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Author(s):
Slavov, Svetoslav [1, 2] ; Matsuno, Alessandra [3] ; Yamamoto, Aparecida [3] ; Otaguiri, Katia [2, 4] ; Cervi, Maria [3] ; Covas, Dimas [1, 2] ; Kashima, Simone [2, 4]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Dept Internal Med, Fac Med Ribeirao Preto, Sao Paulo - Brazil
[2] Univ Sao Paulo, Blood Ctr Ribeirao Preto, Fac Med Ribeirao Preto, Sao Paulo - Brazil
[3] Univ Sao Paulo, Dept Pediat, Fac Med Ribeirao Preto, Sao Paulo - Brazil
[4] Univ Sao Paulo, Dept Clin Toxicol & Bromatol Anal, Fac Pharmaceut Sci Ribeirao Preto, Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: PEDIATRIC REPORTS; v. 9, n. 4, p. 78-80, 2017.
Web of Science Citations: 0
Abstract

Zika virus (ZIKV) is a mosquito-borne flavivirus, which has been related to severe neurological complications in neonates. However, many clinical aspects of the infection remain unclear, especially in pediatric patients. In this case report we describe the uncommon presentation of ZIKV infection in a pediatric patient with acute gastrointestinal involvement hospitalized in a Brazilian Emergency Unit. Dengue hemorrhagic fever was initially suspected, however, the molecular result for Dengue was negative. Molecular testing for other arboviruses (ZIKV and Chikungunya), revealed positive for ZIKV RNA result in both blood and saliva. The ZIKV load in saliva (6.947 copies/mL) was higher than the vetected ZIKV RNA in plasma (1.945 copies/mL). Additionally, the performed abdominal ultrasound revealed mesenteric lymphadenitis without abdominal retention of fluids. The presentation of this case demonstrates that ZIKV can be involved in a broader range of clinical conditions than currently assumed, including pediatric emergencies, especially in regions with extensive ZIKV outbreaks. (AU)

FAPESP's process: 09/16623-1 - Molecular pathogenesis and clinical consequences of the infections caused by the human parvovirus B19 and Human Cytomegalovirus among patients with hemaglobinopathies and haemophilia
Grantee:Svetoslav Nanev Slavov
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 13/08135-2 - CTC - Center for Cell-Based Therapy
Grantee:Dimas Tadeu Covas
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC