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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

EFFECTS OF SURFACTANT TYPE ON RETENTION OF BIOACTIVE COMPOUNDS OF SYZYGIUM AROMATICUM IN SPRAY DRIED LIPID BASED SYSTEMS

Full text
Author(s):
Cortes-Rojas, Diego F. [1] ; Souza, Claudia R. F. [1] ; Oliveira, Wanderley P. [1]
Total Authors: 3
Affiliation:
[1] Univ Sao Paulo, Fac Pharmaceut Sci Ribeirao Preto, Ave Cafe S-N, BR-14040903 Ribeirao Preto, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH; v. 8, n. 12, p. 5057-5064, DEC 2017.
Web of Science Citations: 0
Abstract

This work investigates the effects of the surfactant system used and of spray drying temperature in physicochemical properties and retention of bioactive compounds of lipid based systems loaded with bioactive compounds of Syzygium aromaticum. Seven formulations were prepared, containing Compritol 888 ato and buriti oil as lipids and maltodextrin DE10 as wall material. The surfactants Poloxamer 188, Gelucire 50/13 and Gelucire 50/2 were employed and classified by their hydrophilic-lipophilic balance (HLB). The emulsions were homogenized by means of an ultrasonic probe and spray dried. The eugenol and eugenyl acetate content of each formulation was quantified by HPLC before and after the spray drying process. Higher eugenol retention was obtained for the composition using the amphiphilic surfactant Gelucire 50/13 (R) (HLB of 13). Retention of bioactive marker compounds was affected by spray drying temperatures. A higher spray drying temperature (140 degrees C) increased eugenol loss. The particle morphology was affected by the formulation composition and the drying temperature. (AU)

FAPESP's process: 14/15905-1 - Encapsulation of essential oils in solid lipid carriers: technological development and applications
Grantee:Wanderley Pereira Oliveira
Support Opportunities: Regular Research Grants
FAPESP's process: 11/10333-1 - Microencapsulation and nanoencapsulation of natural compounds by drying technologies
Grantee:Cláudia Regina Fernandes de Souza
Support Opportunities: Research Grants - Young Investigators Grants
FAPESP's process: 12/03427-2 - Microencapsulation and nanoencapsulation of natural compounds by drying technologies
Grantee:Cláudia Regina Fernandes de Souza
Support Opportunities: Scholarships in Brazil - Young Researchers
FAPESP's process: 12/09890-6 - Encapsulation of bioactive compounds from Syzygium aromaticum in solid lipidic carriers
Grantee:Diego Francisco Cortés-Rojas
Support Opportunities: Scholarships in Brazil - Doctorate