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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

LEPR polymorphism may affect energy balance during weight loss among Brazilians obese adolescents

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Corgosinho, Flavia Campos [1, 2] ; Almeida, Sandro Soares [3, 4] ; Tock, Lian [5] ; Pesquero, Joao Bosco [4] ; Araujo, Ronaldo Carvalho [4] ; Grotti Clemente, Ana Paula [6] ; Netto, Barbara Dal'Molin [2] ; da Silveira Campos, Raquel Munhoz [2] ; Landi Masquio, Deborah Cristina [7] ; de Carvalho Ferreira, Joana Pereira [2] ; Sanches, Priscila de Lima [2] ; Ganen, Aline de Piano [7] ; Rogero, Marcelo Macedo [8] ; Oyama, Lila Missae [2] ; Tufik, Sergio [9] ; de Mello, Marco Tulio [10, 2] ; Damaso, Ana Raimunda [2]
Total Authors: 17
[1] Minist Educ Brazil, CAPES Fdn, BR-70040020 Brasilia, DF - Brazil
[2] Univ Fed Sao Paulo, Paulista Med Sch, Programa Posgrad Nutr, UNIFESP EPM Sao Paulo, UNIFESP EPM, Sao Paulo - Brazil
[3] Hosp Israelita Albert Einstein, Sao Paulo, SP - Brazil
[4] Univ Fed Sao Paulo, Paulista Med Sch, Dept Biofis, UNIFESP EPM Sao Paulo, UNIFESP EPM, Sao Paulo - Brazil
[5] Weight Sci, Sao Paulo - Brazil
[6] Univ Fed Alagoas, Fac Nutr, Maceio, AL - Brazil
[7] Univ Sao Camilo, Sao Paulo - Brazil
[8] Univ Sao Paulo, Fac Saude Publ, Dept Nutr, Sao Paulo - Brazil
[9] Univ Fed Sao Paulo, Paulista Med Sch, Dept Psicobiol, UNIFESP EPM Sao Paulo, UNIFESP EPM, Sao Paulo - Brazil
[10] Univ Fed Minas Gerais, Dept Esportes, Belo Horizonte, MG - Brazil
Total Affiliations: 10
Document type: Journal article
Source: Neuropeptides; v. 66, p. 18-24, DEC 2017.
Web of Science Citations: 3

Objective: Leptin is an adipokine released mainly by adipose tissue, with many functions including regulation of energy balance. However, little is known about the effect of LEPR polymorphism on orexigenic and anorexigenic neuropeptides. Thus, the aim of the present study is to verify the influence of LEPR polymorphism (rs2767485) on serum orexigenic (NPY, MCH and AgRP) and anorexigenic (Leptin and alpha-MSH) neuropeptides levels among obese adolescents submitted to 1 year of multicomponent weight loss therapy. Methods: Seventy-six adolescents with obesity were enrolled in 1 year of weight loss therapy including clinical, nutritional, psychological and exercise-related. Blood samples were collected to analyze neuropeptides (NPY, MCH, AgRP and leptin) and LEPR genotyping. Visceral fat was measured by ultrasound and body composition was measured by plethysmography. The parameters were measured at baseline and after one year. Adolescents were grouped according to genotype (TT or CT + CC group). Effect of the weight loss therapy was analyzed through ANOVA and Wilcox, according to normality. Statistic value was set at < 0.05. Results: C-allele carriers have the orexigenic neuropeptides (NPY, AgRP and MCH) levels statistically higher when compared with TT group, at baseline. Furthermore, TT group seems to respond better to the therapy by a greater delta on BMI. Indeed, the data suggest a concomitant increased of AgRP levels in CT + CC genotypes, after weight loss therapy. Conclusion: Both groups responded to the weight loss intervention, however wildtypes (TT) appear to respond to the intervention most optimally with C carries, where post intervention reduction in BMI was significantly greater in wildtypes. The leptin receptor polymorphism seems to affect neuroendocrine regulation of energy balance among adolescents with obesity. (AU)

FAPESP's process: 11/50414-0 - Influence of hyperleptinemia on inflammatory and atherogenic responses in obese adolescents
Grantee:Ana Raimunda Dâmaso
Support type: Regular Research Grants